ACKNOWLEDGMENT The authors VR wish

ACKNOWLEDGMENT The authors VR wish to acknowledge the ??Tamilnadu Pharmaceutical Sciences Welfare Trust, Chennai, India?? for providing financial assistance to perform this study. Footnotes Source of Support: Tamilnadu Pharmaceutical Sciences Welfare Trust, Chennai, India Conflict of Interest: None declared.
Sciatica due to a herniated nucleus pulposus is an important health problem.[1] Although 90% of patients are improved with nonsurgical management, 10%?C15% need surgical management.[2] Epidural corticosteroid injections have been reported to be used to treat sciatica for the last 50 years. Although used frequently in everyday clinical practice, the use of epidural corticosteroid injections for the treatment of sciatica is controversial.

Of 14 controlled trials[3?C16] that have been done so far comparing epidural corticosteroid injections with epidural saline injections, convincing evidence of efficacy of epidural corticosteroid injections is lacking. Butorphanol, a kappa agonist and a weak mu agonist/antagonist with a relatively high lipid-soluble property has been used effectively to produce long-term postoperative pain relief by the epidural route.[17] To our knowledge, no published study has compared the efficacy of epidural butorphanol plus corticosteroid with corticosteroid alone for sciatica due to herniated nucleus pulposus. The aim of our present study was to compare the efficacy of up to 3 epidural butorphanol plus corticosteroid with corticosteroid alone for sciatica due to Batimastat herniated nucleus pulposus.

MATERIALS selleck chem inhibitor AND METHODS Trial designs The study was a single-center, prospective, randomized, double-blind controlled clinical trial, conducted in collaboration of Department of Orthopedics and Traumatology and Department of Anesthesiology of our institution from October 2007 to September 2010. The protocol was approved by the ethics committee of our institution. Randomization was done after we had taken written informed consent from the study participants and obtained baseline information. The random assignment scheme was created from a table of random numbers. Opaque prenumbered envelopes containing random assignments were maintained by the hospital pharmacist.

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