Acknowledgments The research was supported
by the Wroclaw Research Center EIT+ under the Project “Biotechnologies and advanced medical technologies – BioMed” (POIG 01.01.02-02-003/08-00) financed from the European Regional Development Fund (Operational Programme Innovative Economy, 1.1.2). The cytotoxic investigations were carried out with the equipment purchased, thanks to the financial support of the European Regional Development Fund in the framework of the Polish Innovation Economy Operational Program (Contract No. POIG.02.01.00-12-023/08). Conflict of interest The authors declare that they have no conflict of interest. Open AccessThis article is distributed under the terms of the Creative PD0332991 solubility dmso Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Electronic supplementary material Below is the link to the electronic supplementary material. Supplementary material 1 (DOCX 120 kb) References Balenci D, Bonechi G, D’Amelio N, Gaggelli E, Gaggelli N, Molteni E, Valensin G, Szczepanik W, Dziuba M, Święcicki G, Jeżowska-Bojczuk M (2009) Structural features and oxidative stress towards plasmid DNA of apramycin LDC000067 mouse copper complex. Dalton Trans 7:1123–1130PubMedCrossRef Baron ESG,
DeMeio RH, Klemperer F (1936) Studies on biological Dipeptidyl peptidase oxidations: V. Copper and hemochromogens as catalysts for the oxidation of ascorbic acid. The mechanism of the oxidation. J Biol Chem 112:625–640 Bertini I, Pierattelli R (2004) Copper(II) proteins are amenable for NMR investigations. Pure Appl Chem 76:321–333CrossRef Chibber S, Hassan I, Farhan M, Naseem I (2012) Light-mediated interaction of methotrexate with transition metal Cu(II). Med Chem Res 21:2379–2387CrossRef de Hoog P, Boldron C, Gamez P, Sliedregt-Bol K, Roland I, Pitie M, Kiss R, Meunier B, Reedijk J (2007) New approach for the preparation of efficient DNA-cleaving agents: ditopic copper–platinum complexes based on 3-clip-phen and buy Cilengitide cisplatin. J Med Chem 50:3148–3152PubMedCrossRef Devereux M,
Shea DO, Kellett A, McCann M, Walsh M, Egan D, Deegan C, Kedziora K, Rosair G, Muller-Bunz H (2007) Synthesis, X-ray crystal structures and biomimetic and anticancer activities of novel copper(II) benzoate complexes incorporating 2-(4′-thiazolyl)benzimidazole (thiabendazole), 2-(2-pyridyl)benzimidazole and 1,10-phenanthroline as chelating nitrogen donor ligands. J Inorg Biochem 101:881–892PubMedCrossRef Dunger A, Limbach HH, Weisz K (1998) NMR studies on the self-association of uridine and uridine analogues. Chem Eur J 4:621–628CrossRef Franco R, Panayiotidis MI, Cidlowski JA (2007) Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation.