OUP, rapid clearance and low Zellpermeabilit t, high plasma protein binding, and h Here effective concentrations are significant obstacles to the successful delivery of the pin D on cancer cells. We have been the Procollagen C Proteinase synthesis of poly-L-glutamine Acid conjugate D pin Zellpermeabilit t of the pen improves D. reported increased Hte cellular Re ROS levels leads to the absorption of induction of apoptosis and improved survival rate of M mice bearing ip leukemia reported chemistry. In this study we investigated the potential of a new combination of idarubicin and pin D, twice as conjugates of medicaments PGA delivered over the administration of either drug alone. Ida, an anthracycline derivative, was effective as first-line treatment of acute leukemia Chemistry and several other cancers. Anthracyclines act by mechanisms, including several DNA intercalation, inhibition of topoisomerase II and induction of p53-mediated apoptosis. Zellsch Was the anthracycline-iron complexes through the generation of ROS as an important mechanism in their cytotoxicity t. The generation of ROS is dependent Dependent and is increased by reducing the complex of anthracycline Ht thiol to Fe Fe anthracycline redox-active. This reduction leads to a further generation of hydroxyl radicals, which are among the beautiful dlichen ROS via Fenton reactions. It was also demonstrated that the anthracycline-iron complex can catalyze the consumption of oxygen by thiols and hen, the production of ROS increased. We assumed that the provision of CDD D co and Ida pen is very effective in its anti-cancer drugs and reduce adverse events associated with the administration of Ida leads to an increase Increase the therapeutic index linked. To the best of our knowledge, this is the first report on the study of the combination of an aminothiol anthracyclinewith for cancer therapy of CSD.
Conjugation of drugs to linear polymers such as PGA, HPMA copolymer and polyethylene glycol on L Sbare linker has several advantages. It was shown that the plasma circulation rate Ngern become engaged, The improvement of enrichment in L Solubility of drugs. More traffic makes A increased Hte glicht passive enrichment in tumors. A further improvement in tumor uptake can Be System in solid tumors and poor lymphatic drainage, the main source of freedom achieved for macromolecules because of the leaks, the distorted vascular. Polymer-drug conjugates were also examined for cancer treatment forcombination to improve therapeutic responses. This closing t the use of simple drugs conjugated polymers in combination with chemotherapy, synthesis of various functional compound and delivers two PDC. PGA is a linear homopolypeptide of L glutamine Acid monomer, an amino Acid is endogenous. It is very sensitive to cleavage by lysosomal cysteine proteases, cathepsins, and Gamma Secretase can be administered at very high levels without side effects. PGA was in big investigated em style for the conjugation of drugs. PGA-PTX conjugate showed a strong antitumor effect in pr Clinical studies and the results of a Phase III clinical trial in patients with non-small cell lung cancer were recently VER Published in which the conjugate is controlled most effectively chemotherapy, but has been observed gr ere anti-cancer effect in female patients. The CSD of the present study were examined.