Those who completed the entire Caspase 3 course of treatment, the dose of doxorubicin in patients treated with lower DD regime, w While the dose of paclitaxel was comparable, and the significant difference in efficacy was observed in patients with TN is likely the differences in time or administration of a third drug. Several prospective clinical studies, the administration of DD regime is not obtained Ht or increased Hte CRP. In an analysis of data from seven studies that included neoadjuvant more than 3000 patients, the PCR rate increased with cumulative doses of anthracyclines and taxanes Ht, with the addition of capecitabine or trastuzumab, and the number of cycles of chemotherapy. The effect on the number of cycles of chemotherapy pronounced Gter was in patients with ER / PR-positive tumors. Although the pCR h Ago was in patients with ER / PR negative tumors by these studies, this analysis indicates a first report that the difference in pCR diet-induced SD is caused by the pCR rates significantly h Forth as in tumors TN .
Interestingly, the results of a recent meta-analysis of adjuvant trials have also indicated that the benefits of chemotherapy in patients with SD ER / PR negative tumors reserved. In summary, the current data, the superiority of a system of DD levels in achieving PCR in patients with breast carcinoma treated with neoadjuvant chemotherapy. However, the difference in performance substantially on pCR is significantly h Forth in patients with tumors TN. H Here CRP levels was also associated with an improved chance of survival in patients with breast cancer, TN. observed when using non-invasive functional and molecular imaging apoptosis. Since the cell durchl Runs apoptosis, there are a number of steps in the process studied with very different modality can be Th. Among them, the exposure of phosphatidylserine occurs in the very heat of tt No apoptotic events, in events such as nuclear condensation and DNA ladder. In addition, PS exposure is an almost universal event in apoptosis, and has a very rich target that is easy to train Accessible to the extracellular Ren surface Surface of the plasma membrane. Annexin V, a human endogenous protein having a molecular weight of 36 kDa, has a high affinity t to PS.
Due to the high affinity t for apoptotic cells, no Immunogenit t and the lack of toxicity T in vivo, annexin V to detect apoptosis sumatriptan and probe the dominant image. Tats Chlich was annexin V with 125 I, 123 I, 111 marks in, 99m Tc and single photon emission computed tomography. Clinical studies in patients with various tumor types have shown that annexin V imaging is a promising technique to best induce the occurrence of apoptosis by chemotherapy and radiotherapy Term is. For example, applied 99m Tc annexin V scintigraphy for human tumors after the first chemotherapy showed a tumor uptake to prove that apoptosis was initiated. In comparison with SPECT positron emission tomography has the advantage that it is more sensitive and quantitative. Annexin V was by radioisotopes, including normal positron emission tomography, 124I and 68Ga and 18 denotes F for PET. It has been found that induces apoptosis by irradiation or chemotherapy either be identified with in vivo imaging or ex vivo autoradiography using.