WBC differential count showed a significant increase in the levels of serum monocytes in the low dose group relative to the control group (P = 0.023), (Fig. 4B). Kerosene supplementation had an inflammatory effect on the stomach lumen in all the test groups. This effect was demonstrated by the active and chronic inflammation observed histologically (Fig. 5A-C). From these findings it can be concluded that kerosene supplementation causes gastritis. The inflammation was observed to be more pronounced at the gastro duodenal junction of the stomach. Although studies have shown that H pylori is the chief cause of gastritis in Kenya [52], there may be need to re-examine the contribution of

dietary kerosene supplementation especially among school going children. From data obtained during an earlier pre animal study survey (Fig. 1B), 47.8% of respondents with kerosene supplementation

reported that they Selleckchem Nutlin-3a had experienced either ulcers or heart burns. This points to the role that kerosene supplementation in Kenyan schools may have in the high number of cases of students with gastritis. There were no significant morphological changes on the brain (Fig. 6A-C) with the parenchyma, brain stem and cerebellum all showing lack of abnormalities (pathology). Similarly, images were obtained from the esophagus from all three groups (Fig. 6D-F) also indication lack of abnormalities. The kerosene doses used in our study were Selleck PI3K inhibitor therefore found not toxic to the brain and the esophagus. This study established for the first time that kerosene supplementation results in increased serum T levels which have been shown to be directly associated with higher sex drive (libido). Based on these findings therefore, crude kerosene supplementation is ineffective in controlling sexual hyperactivity

in boarding schools. Our findings also demonstrate the relationship between increased serum T levels with increased aggression. Kerosene supplementation in boarding schools may result to similar effects. These findings may explain the increase in the numbers of teenage pregnancies, rebellion to authority and violence as seen in school going teenage children. The findings from the present study http://www.selleck.co.jp/products/ch5424802.html further show that crude kerosene supplementation caused gastritis in our animal model. Kerosene supplementation in schools thus may be a contributing factor in the increasing cases of gastritis and ulcers among students. We recommend that alternative, effective and safe ways to control sexual hyperactivity that are scientifically proven need be sought as a replacement to kerosene dietary supplementation. The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research findings reported. This research did not receive any specific grant from any funding agency in the public, commercial or not-for profit sector *These two authors contributed equally to this work.