The physicians recommended no prophylaxis, graduated stockings, drugs, and graduated stockings and drugs in 63.9, 25.5, 1.3, and 9.3%, respectively. Physicians (47.3%) RAD001 did not specify the length of the stockings,

whereas 7.7 and 45.1% recommended knee- and thigh-long stockings, respectively. The frequency of recommended TP measures with regard to the three risk groups according to the Vienna and Hall recommendations24,25 is given in Figures 1 and 2. Among the 32 travelers recommended to use drugs as prophylactic treatment during travel, 2 and 5 travelers had already been on permanent therapy with phenprocoumon and ASA, respectively. Of the remaining 25 patients, 13 and 12 patients were advised to use ASA and low-molecular weight heparin (LMWH), respectively. The recommendation on how to apply the medication showed a wide range of variations (Tables 2 and 3).

Among the travelers advised to apply LMWH during their travel, 5/0, 3/8, and 4/4 travelers had a low, medium, and high TR according to the Vienna/Hall classification.24,25 Q3 was answered by 248 travelers. The predominantly used means of transport during the past journey was aircraft, car, bus, train, and ship in 80.7, 11.5, 17.7, 3.3, and 2.9%, respectively. Travelers, 3.7, 25.2, 50, 14.6, and 6.5%, reported that they had been seated during their journey for less than 4, 4 to 8, 8 to 12, 12 to 16, and more than 16 hours, respectively. The frequency of the performed TP with regard to the three risk groups see more in accordance to the Vienna and Hall recommendation24,25 is provided in Figures 3 and 4, respectively. Overall, travelers used stockings, drugs, and stockings and drugs in

23.0, 11.7, and 15.3%, respectively. Knee- or thigh-long stockings were used in 38.9 and 60.0%, respectively. Amino acid Travelers (92.6%) wearing stockings did not report any side effects. Two travelers wearing thigh-long and one traveler wearing knee-long stockings (3.2%) felt pain in the legs while wearing the stockings. One traveler with thigh-long stockings had a skin rash for more than 3 days after having worn the stockings. One traveler reported a swelling of the leg or uncomfortness. Both travelers had worn knee-long stockings. One traveler using thigh-long stockings did not further specify the experienced side effect. Three travelers had been on permanent therapy with phenprocoumon or ASA. Of the remaining 62 travelers, 69.4, 29.0, and 1.6% used ASA, heparin, and even both as prophylactic medication, respectively. With regard to experienced side effects, one patient taking ASA indicated having had angioedema. One traveler using ASA and heparin in addition to knee-long stockings for prophylaxis reported no further specified leg swelling, indicated as possible side effect or clinical symptom for deep vein thrombosis (DVT). Unfortunately, the traveler did not report whether the suspicion was proven later on. Overall, 17 travelers (6.