Goal temperature was maintained within a narrow
range, and thermogenic shivering did not occur. These findings suggest a useful new modality to induce therapeutic hypothermia. (C) 2013 The Authors. Published by Elsevier Ireland Ltd. All rights reserved.”
“OBJECTIVE: To investigate the impact of transgastric peritoneal access on plasma biomarkers of acute www.selleckchem.com/products/AZD1152-HQPA.html inflammatory response in comparison to laparoscopy.
METHODS: This was a prospective and comparative study in a porcine model. Transgastric peritoneal access performed by natural orifice transluminal endoscopic surgery was compared with laparoscopy. Laparotomy and sham groups were used as positive and negative controls, respectively. Thirty-four pigs were assigned to receive transgastric natural orifice transluminal endoscopic surgery (n = 12), laparoscopy (n = 8), laparotomy Selleckchem ABT 263 (n = 
or a sham procedure involving only anesthesia (n = 6). In the natural orifice transluminal endoscopic surgery group, peritoneoscopy was performed with a gastroscope via transgastric access. Blood samples were collected at baseline and 1, 3, 6, 9 and 24 h after the surgical procedure for measurement of interleukins 1 beta, 6 and 10 and tumor necrosis factor-alpha. A complete blood count was performed, and C-reactive protein levels were measured at baseline and at 24 h.
RESULTS: All surgical and endoscopic procedures were performed without major complications. Peritoneal cavity
inventory showed no signs of peritonitis in any animal. Interleukin 1 beta, interleukin 10 and tumor necrosis factor-alpha levels were below the threshold of detection. The mean level of interleukin 6 was statistically significantly higher in the laparotomy group than in the other groups (p < 0.05), with no significant differences among the sham, laparoscopy and natural orifice transluminal endoscopic surgery groups (p > 0.05). C-reactive protein analysis indicated
significant increases in all groups, Napabucasin JAK/STAT inhibitor with no differences among the groups. Complete blood count analysis showed no differences among the groups.
CONCLUSIONS: Based on the observed interleukin 6 patterns, the systemic inflammatory response resulting from transgastric peritoneal access by natural orifice transluminal endoscopic surgery is similar in intensity to the response that occurs after laparoscopy.”
“Objective. To conduct an audit of the Omniview-SisPorto (R) central monitoring station (CMS) and determine the effect of the measures undertaken to correct identified problems. Methods. All cardiotocograms (CTGs) recorded in randomly selected days of 2006 and 2009, both in the outpatient clinic and labor ward, were reviewed to assess the following parameters: tracing identification, duration, signal quality, signal loss, acquisition method, and time elapsed between tracing-end and birth. A random sample of cases was compared with original paper recordings and 25% of CTGs were re-retrieved for comparison with first retrieval. Results.