05), but there were no significant differences for other cardiovascular

risk factors (all Crizotinib ROS1 p>0.05). The proportions of male sex, overweight, obesity, dyslipidaemia, DM, IFG, hyperuricaemia and BMI, and levels of TC, LDL-C, TG, FPG and UA were higher in the high-range prehypertension group than in the optimal BP group (all p<0.05). Compared with low-range prehypertension, the proportions of overweight, dyslipidaemia and IFG were higher in the high-range prehypertension (all p<0.05; table 3). Table 3 Cardiovascular risk factors in different subranges of prehypertension Risk factors associated with prehypertension The multivariable-adjusted risk factors associated with prehypertension are presented in table 4. High BMI (overweight/obesity) was the most important risk factor for prehypertension (OR=2.84, 95% CI 1.55 to 5.20, p<0.001). Age (per 10 years, OR=1.21, 95% CI 1.02 to 1.44, p=0.03), male sex (OR=2.19, 95% CI 1.39 to 3.45, p<0.001) and hyperuricaemia (OR=1.70, 95% CI 1.14 to 2.54, p=0.009) were also significantly associated with prehypertension. Furthermore, collinearity statistics were >0.4

for tolerance and <2.5 for the variance inflation factor, suggesting that multicollinearity was not a concern among the independent variables. Table 4 Multivariate logistic regression analysis for risk factors of prehypertension Discussion In this study, we found that prehypertension is highly prevalent in the Shunde District, Guangdong Province. Prehypertensive individuals presented with other risk factors associated with CVD, such as overweight, dyslipidaemia, impaired glucose and hyperuricaemia. Furthermore, combined cardiovascular risk factors were more significant in people with high-range prehypertension. To the best of our knowledge, this is the first study to show that there was a significant heterogeneity of combined risk factors within the prehypertensive subgroups. Many epidemiological studies have demonstrated that prehypertension is an important public health problem. However, the prevalence GSK-3 of prehypertension

in different countries and districts differs significantly, and may be influenced by different regional factors, such as climate and lifestyle, as well as ethnicity. At the beginning of this century (2000–2001), a cross-sectional survey found that the prevalence of prehypertension was 21.9% among Chinese participants aged between 35 and 74 years.3 However, in other subsequent studies, the prevalence of prehypertension was significantly higher than this ratio. In rural northeastern China, the prevalence of prehypertension was 35.1% in men and 32.5% in women,15 and up to 40% in the whole population from urban areas of northeastern China,16 which may be associated with the cold climate and high sodium diet.