, 2002). Several studies have shown substantially weaker associations between cannabis use and externalizing behaviour after statistical control for factors such as social economic status and use of other substances (e.g. Korhonen et al., 2010). However, most studies do

show some residual variance in associations between externalizing behaviour and cannabis use that cannot be explained by environmental factors (Fergusson et al., 2007, Fergusson et al., 2002 and Pedersen et al., 2001). The temporal order of cannabis use and both externalizing and internalizing behaviour has not yet been disentangled (Fergusson et al., 2002 and Monshouwer et al., 2006). Most longitudinal evidence supports the self-medication hypothesis, which states that externalizing problems MG-132 mw precede the use of cannabis at this age (King et al., 2004, Fergusson et al., 2007 and Pedersen et al., 2001). There is also evidence to suggest that externalizing behaviour during adolescence precedes cannabis use in early adulthood (Hayatbakhsh et al., 2007b). Although it is difficult to control for all potential confounders

simultaneously, PCI-32765 some of these studies did not control for important potential confounders, such as SES, use of other substances and parental psychopathology, and therefore may have left open the possibility of shared causes more than necessary. For internalizing behaviour, the relationship is even more complex: firstly, compared to externalizing behaviour problems, there is less evidence for an association between cannabis use and internalizing behaviour problems (Monshouwer et al., 2006). In several studies that did initially find a significant association between cannabis use and internalizing behaviour, the association became non-significant after statistical control for confounding Terminal deoxynucleotidyl transferase variables (Harder et al., 2008 and McGee et al., 2000). Nonetheless, there are some studies that have found evidence for the self-medication hypothesis, with internalizing behaviour problems preceding cannabis use

at later age (King et al., 2004 and Wittchen et al., 2007). Again, shared causes cannot be ruled out, as the associations may be explained by residual confounding (Fergusson and Horwood, 1997, Fergusson et al., 2002 and Hayatbakhsh et al., 2007a). There is also (contrasting) evidence suggesting that internalizing behaviour in young adolescence is not related to substance use at a later age, including the use of cannabis (Alati et al., 2008, Hayatbakhsh et al., 2008 and Ferdinand et al., 2001). Thus, in general, evidence regarding (the direction of) associations between cannabis use and internalizing/externalizing behaviour problems in adolescence is not yet convincing, which is mainly due to the fact that most studies did not analyze temporally bi-directional associations (i.e.