97% (N = 83), and children 39.3% (N = 68). The male female ratio was 1.09:1. The age range was from 5 to 59 years with the mean (SD) being 19.7 years (± 10,5), whereas 83.5% of patients were under 30 years old. According to the histopathology reports, Group A where normal appendix was found comprised 25 (14.45%) patients, whereas inflamed appendix was found in 148 (85.5%) patients. Among patients with a positive appendicitis, 36 (20.81%) belonged to group Group B with acute simple appendicitis and 112 (64.74%) had Adriamycin ic50 a ruptured/perforated/gangrenous appendix (Group-C, complicated appendicitis). The rate of perforated appendicitis was 12.1% (Table 1). Table 1 Distribution

of histopathologic features of appendix by sex Histopathology of Appendix Female Male N % Group – A Normal appendix 20 5 25 14.5 Group – B Catarrhal App. 2 0 2 1.2 (Non-complicated appendicitis) Phlegmonous App. 23 11 34 19.7 Group – C Gangrenous App. 31 60 91 52,6 (complicated appendicitis) Perforative App. 7 14 21 12,1 Total N 83 90 173 100   % 48 52 100   Among the patients in Group A, the most common diagnoses associated with primary negative appendectomy included nonspecific abdominal pain 15 (8.7%), ruptured ovarian cysts 4 (2.3%), mesenteric lymphadenitis 5 (2.9%), and urinary Selonsertib solubility dmso infection 1 (0.6%). In Group A the CRP values ranged from 0 to 96 with a mean of 10.6 mg/l. In Group B these values were from 0 to 192 with a mean

value of 37 mg/l, and in Group C from 0 to 192 with a mean

of 79.2 mg/l. The serum CRP levels were normal in 22 patients with acute appendicitis. Thus, the false-negative rate of CRP was 12.71 percent. Of the 25 patients with normal appendectomy, serum CRP levels were slightly elevated in 7 patients. A false-positive rate of CRP was 4.05 percent. Further, based on the surgeons’ clinical impression, the diagnosis was true in 87.28% (N = 151) and false in 12.72% (N = 22) patients. In the present Erastin study, the positive predictive value of the CRP was 94.7%, specificity 72%, sensitivity 85.1%, and JAK inhibitor accuracy 83.2%. Similarly, when the WBC count was assessed, Group A varied from 5.3 to 14.7 (mean 8.8 x109/l), Group B from 5.0 to 28.0 (mean 12.6 x109/l), and Group C from 5.0 to 28.0 (mean 15.6 x109/l). The false positives were 4.62% and false negatives were 12.72% with a sensitivity of 85.1% and a specificity of 68%,; the positive predictive value was 94% and the accuracy was calculated to be 82.6%. The neutrophil percentage in Group A varied from 54.2 to 88.6 (mean 71.5), in Group B from 56.2 to 94.3 (mean 79.8) and in Group C from 60.7 to 96.6 (mean 84.0). The false positives were 4.62% and false negatives 17.92% with a sensitivity of 79.1% and the specificity 68%; the positive predictive value was 93.6% and the accuracy was calculated to be 77.5%.