Additional sections should include proximal and distal margins, radial margin (if not included in tumor sections), any additional polyps or lesions, and random uninvolved colorectum. After taking the above sections, the mesenteric fat or perifind more colorectal soft tissue is stripped off and dissected for lymph nodes. All grossly negative lymph nodes are entirely submitted for microscopic examination. Inhibitors,research,lifescience,medical Grossly positive lymph

nodes may be submitted in part or entirely depending on their size. A polypectomy specimen is inked at the cauterized base, but the stalk may retract and thus be difficult to identify. The specimen is either bisected or serially sectioned depending on its size, and entirely submitted. Sectioning should follow the vertical plane of the stalk to maximize the histologic evaluation of polypectomy margin and submucosal Inhibitors,research,lifescience,medical involvement. If the specimen is received in multiple

pieces, however, margin evaluation may become impossible. Precursor lesions It has been well established that the vast majority of colorectal adenocarcinomas derive from precursor lesions such as adenomas and dysplasia. Residual adenoma is a common Inhibitors,research,lifescience,medical finding in colorectal adenocarcinomas. Endoscopic polypectomy decreases the incidence of colorectal cancers in treated population and prevents death from colorectal cancer (35,36). Some of the common precursor lesions are discussed here. Adenomas At least half of adults in Western

countries will have an adenomatous polyp in their lifetime and one-tenth of these lesions will progress to adenocarcinoma Inhibitors,research,lifescience,medical (37). The risk increases after the age of 50. Endoscopically, adenomas can be pedunculated or sessile. By definition, adenomas are clonal lesions that show at least low grade dysplasia characterized by enlarged, hyperchromatic and elongated (pencillate) nuclei Inhibitors,research,lifescience,medical arranged in a stratified configuration along the basement membrane. The adenomatous cells may show mucin depletion and increased apoptotic activity. Interestingly, adenomatous polyps appear to develop through a “top-down” mechanism (38). As such, small lesions will often only have adenomatous epithelium in their superficial portions. Conventional GBA3 adenomas are subclassified as tubular, tubulovillous and villous based on their architectural features (Figure 9). Tubular adenomas are composed of simple crypt-like dysplastic glands and contain <25% villous component. Villous adenomas consist of >75% villous component that resemble finger-like projections. Tubulovillous adenomas are intermediate lesions with 25-75% villous component. Adenomas that are large in size (>1 cm) or predominantly villous, or contain high grade dysplasia (discussed below) are considered “advanced adenomas” (39), which require more aggressive endoscopic surveillance. Figure 9 Examples of tubular adenoma (A.