Biopsies from patients with CD were obtained from the edge of ulceration’s or aphtoid lesions if present, and from macroscopic non-inflammed areas using a standard biopsy forceps. IAP (intestinal alkaline phosphatase) was quantified from each specimens using ELISA. Results: A total of of
32 consecutive patients (25 UC, 17 CD) were included in the study. Median age and median disease duration of 25 patients with UC were 45.0 years and 6 years, respectively. The extent of disease was proctitis in 5 patients (20%), left-sided colitis in 11 (44%), extensive colitis HIF-1 cancer in 119 (36%). Median age and median disease duration of 17 patients with CD were 21.0 years and 4 years, respectively. The IAP protein level (58.7 ± 38.0 ng/mL) (median value, 53.7 ng/mL; range, Barasertib solubility dmso 13.1∼125.3) of the inflamed mucosa in patients with UC was higher than that (27.6 ± 10.9 ng/mL) (median value, 22.9 ng/mL; range, 15.4∼44.4) of non-inflamed mucosa in patients with
UC (p = 0.022). We found a higher IAP protein level in the inflamed mucosa in CD (66.4 ± 27.3 ng/mL) (64.7, 40.9∼111.1) compared with non-inflamed mucosa in
CD (31.3 ± 11.8) (29.4, 17.4∼52.0) (p = 0.028). Conclusion: iAP expression of inflamed mucosa in patients with IBD was higher than that of non-inflammed mucosa. It is necessary Protein kinase N1 to do further study to evaluate the role of iAP in patients with IBD. Key Word(s): 1. Intestinal alkaline phosphatase; 2. inflammatory bowel disease Presenting Author: YONG HUN KIM Additional Authors: SEONG RAN JEON, JIN OH KIM, HYUN GUN KIM, TAE HEE LEE, JUN HYUNG CHO, BONG MIN KO, JOO YOUNG CHO, JOON SEONG LEE Corresponding Author: YONG HUN KIM Affiliations: Soonchunhyang University College of Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University College of Medicine, Soonchunhyang University College of Medicine Objective: Double-balloon enteroscopy (DBE) has been introduced since 2003 in Korea and used for 10 years.