Conclusion: EUS/EUS-FNA is very useful in confirming of etiology of RAP with cystic lesions. Some cystic lesions of RAP were found as cause, instead of outcome of this disease by EUS/EUS-FNA. Key Word(s): 1. pancreatitis; 2.
reccurent; 3. etiology; 4. EUS/EUS-FNA; Presenting Author: KARAMROMEO SINGH Additional Authors: ASHIM DAS, VIRENDRA SINGH, KAUSHALK PRASAD, SREEKANTH APPASANI, JAHANGEERBASHA MEDARAPALEM, KARTAR SINGH, RAKESH KOCHHAR Corresponding Author: RAKESH KOCHHAR Affiliations: PGIMER Objective: AIM:To prospectively evaluate pattern of liver and pancreatic involvement prospectively using fibroscan and EUS and retrospectively on autopsy data in alcoholics Methods: MATERIALS & METHODS: Daily ICG-001 nmr alcohol consumption was evaluated.
Patients with BMI>40, HBV, HCV, HIV, gallstones and diabetes mellitus were excluded. In group A, 68 ALD patients(mean age-42yrs, all males) were classified as alcoholic hepatitis/cirrhosis based on features of portal hypertension. Pancreatic parenchymal-ductal changes were characterized using EUS-Rosemont’s classification. In group B, 70 symptomatic ALP patients with USG/CT/EUS/ERCP Mitomycin C in vivo features on were fibroscanned and graded for liver stiffness. In group |C autopsy liver and pancreas specimens of 51 alcoholics(mean age-46yrs, all males) who died of alcohol related liver and pancreatic diseases from Jan 2008-Dec 2010 were analyzed. Results: RESULTS: Of 68 ALD patients(group A), 40%(27)
had pancreatic involvement on EUS (chronic pancreatitis(CP)-7%, suggestive CP – 12%, indeterminate CP-21%). Of 70 ALP patients (group B), 26(37%) had liver involvement on fibroscan(cirrhosis-6%, severe fibrosis-13%, significant fibrosis-19%). Altered liver function with raised bilirubin, AST, ALT, ALP and low albumin were observed in 23(30%),39(51%),24(32%),27(35%) and 27(35%) patients respectively. Of 51 autopsy patients (group C), 82%(42) had ALD and 18%(9) had ALP. Of these 42 ALD patients, 25(60%) had some form of pancreatitis(CP-31%,acute-on-CP-17% and acute selleck screening library pancreatitis-12%). Of these 9 ALP patients, 44%(4) had liver injury (fatty liver-33%,steatohepatitis-11%). There was no difference in age, type, frequency and pattern of alcohol consumption in both groups. Amount and duration of alcohol intake in ALD(211gm,21yrs) was more than in patients with ALP(183gm,13yrs)(p=0.038, p=0.003). Conclusion: CONCLUSIONS: Our study shows that 37% ALP had evidence of liver disease on fibroscan and 40% ALD had evidence of pancreatic disease on EUS. High degree of co-existence of ALD and ALP (60%) was noted in our autopsy data. ALD patients consumed more alcohol and for longer periods than ALP. This is the first study of its kind. Key Word(s): 1. Alcohol; 2. Fibroscan; 3. EUS; 4.