Early diagnosis and appropriate treatment of malignant tumors offers the best prognosis for the patient.”
“Objectives: To clarify the association of kallikrein-related peptidase 3 (KLK3) rs2735839 G/A polymorphism with serum AZD6738 prostate-specific antigen (PSA) levels in Japanese men. Methods: Subjects were participants of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study who visited the Seirei Preventive Health Care Center in Shizuoka, Japan. Among the 5,040 individuals aged 35-69 years who were enrolled in 2006-2007, serum PSA

data were available for 2,323 male subjects without a past history of prostate cancer. The diagnostic criteria for PSA positivity was PSA >= 4.0 ng/ml. Genotyping of the KLK3 polymorphism was conducted by the polymerase chain reaction with the confronting two-pair primers (PCR-CTPP) method. Results: The mean +/- SD of PSA levels (mg/dl) were 1.54 +/- 1.73 for those with KLK3 rs2735839 GIG genotype, 1.34 +/- 1.33 for G/A, and 1.20 +/- 1.23 for A/A, which was significantly different (p < 0.0001). The age-adjusted odds ratios of PSA test positivity were 0.62 (95% confidence interval 0.41-0.94) for those with G/A + A/A relative to those with G/G. Conclusions:

The present study revealed that the KLK3 rs2735839 G eFT508 mw allele was significantly associated with higher serum PSA levels also in Japanese. Copyright (C) 2012 S. Karger AG, Basel”
“The polyphenolic profile of a leaf extract of the Mauritian endemic plant, Eugenia pollicina, was assessed as a source of natural antioxidants. The amounts of flavan-3-ol derivatives determined by HPLC, were in the order of (-)-epicatechin (EC) > (-)-epigallocatechin gallate (EGCG) > (+)-catechin (C) > (-)-epicatechin gallate (ECG) with the levels of Procyanidin B2 and B1 dimers ranging from 1 to 3 mg g(-1) FW. The trolox equivalent antioxidant capacity and ferric reducing antioxidant power values were 796 mu mol g(-1) FW and 302 mu mol g(-1) FW respectively. E. pollicina extracts also strongly inhibited the FeCl(3)

and ascorbate-dependent microsome lipid peroxidation, a function that is AZD4547 linked to their flavonoid contents. The extent of DNA damage induced by the extract under study in the copper-phenanthroline assay was lower than the effect of a reference of 240 mu M ascorbate. E. pollicina extracts also inhibited lipid autoxidation in the 30% (v/v) olive oil and soybean oil oil-in-water (O/W) emulsions and was effective in slowing down the formation of hydroperoxides in the emulsions during 13 days storage at 40 degrees C as determined by the peroxide, conjugated diene and para-anisidine values. The high levels of total phenolics, flavonoids and procyanidins measured indicate that E. pollicina is a potential source of antioxidants relevant to the maintenance of oxidative stability of the food matrix, cosmetics and/or pharmaceutical preparations. (C) 2010 Elsevier Ltd. All rights reserved.