Cancer growth in non-castrated ostate m Nnliche rats. Interestingly, when rats were treated with dutasteride, the growth of prostate cancer was significantly reduced, but not in the same Ma E as castration, the testosterone is suppressed, 14 and thus supports the notion that although it is not the testosterone so EPO906 Epothilone B m Chtig as DHT can still stimulate cell metabolism and the malignant growth to some extent. Xu and his colleagues also reported that, although an oral mice are daily treatment with finasteride significantly reduced the growth of human LNCaP prostate cancer xenograft in non-castrated male pattern naked M, The reduction was not as dramatic as the Equimolar dose with dutasteride. The fact that dutasteride reduces the growth on a gr Eren Ausma than finasteride in M both intact and castrated mice also supports the importance of type 1 inhibition.
14 results of phase II, double-blind, placebo-controlled, comparative study with various doses has been shown clearly that the suppression of serum DHT with dutasteride significantly gr as he was with finasteride, dutasteride, and the reaction to be less variable. Serum DHT compared again less than 20% of baseline values within 4 weeks of treatment in patients taking finasteride, with 16 weeks in patients given dutasteride.16 In the same study reported Roehrborrn and colleagues17 DHT suppression more than 90% in 85 , 4% of patients treated with dutasteride and only 2.2% of patients treated with finasteride. In comparison, more than 70% suppression of DHT observed in 100% of the dutasteride-treated patients and 49% of finasteride-treated patients.
17, 18 In another approach, have shown Gleave and colleagues19 that M Men treated with dutasteride for 4 months prior to radical prostatectomy had significantly lower levels of intraprostatic DHT but testosterone concentrations were h ago than in untreated prostatectomy. Moreover, had M Men, who U dutasteride again have lower tumor volume, without significant Changes in scores to adversely caning processing or atrophy, than those who again U surgery alone.19 Similarly Iczkowski and colleagues20 showed that in cancer tissue nnern of M That again u prior to surgical treatment with dutasteride in comparison to that of the men treated with finasteride, decreased tumor volume of FA is significant, the percentage of atrophic epithelium was increased ht and both the ratio ratio stroma / gland and the effect the change of treatment has doubled.
The F Ability, a ph Phenotypic Ver To induce change in both the benign and neoplastic prostate on an R Potential chemopr Their preventive dutasteride.20 for prostate-specific antigen as a marker whose expression is regulated by androgens, and its concentration are serum used in the detection of prostate cancer. May, however, treatment with 5 IRA, such as finasteride or dutasteride results in decreased serum levels of PSA, the interpretation of test results do difficult.21 The randomized, double-blind, controlled EAA active international comparative study of enlarged Erte was prostate, finasteride and dutasteride entered treatment born on the same median PSA reduction of greater than 55% after 12 months. Finasteride in the treatment Ple Study found an average Change of 57% at 4 years.22 trademarks and colleagues, 23 a rating of three large scale phase III trials