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Jones SF, Burris HA III, Dumez H, et al. Phase I accelerated dose escalation, pharmacokinetic and pharmacodynamic study of PF 03814735, an oral aurora kinase inhibitor, in patients with advanced solid tumors: Preliminary results. Journal of Clinical Oncolgy 2008,26:2517. Dar et al. Page 14 Mol Cancer Ther. Author manuscript, available in PMC 2011 February 2. NIH PA Author Manuscript NIH PA Author Manuscript NIH PA Author Manuscript 75. Yang H, He L, Kruk P, Nicosia SV, Cheng JQ. Aurora A induces cell survival and chemoresistance by activation of Akt through a p53 dependent manner in ovarian cancer cells. Int J Cancer 2006,119:2304�?2. Dar et al. Page 15 Mol Cancer Ther. Author manuscript, available in PMC 2011 February 2. NIH PA Author Manuscript NIH PA Author Manuscript NIH PA Author Manuscript Figure 1.
Schematic diagram of Aurora A, B, & C kinase domains. N & C terminal domains contain most of the regulatory sequences. The central domain consists of catalytic kinase domain and activation loop. D Box at the c terminal domain is the destruction box. Brown box Activation loop, Black box destruction box at C terminus, Light green box destruction box at N terminus, Light green box Kinase domain. Dar et al. Page 16 Mol Cancer Ther. Author manuscript, available in PMC 2011 February 2. NIH PA Author Manuscript NIH PA Author Manuscript NIH PA Author Manuscript Figure 2. Overvie