Gastroenterology 2012,142(1):140–151. e12PubMedCrossRef 29. Bondia-Pons I, Ryan L, Martinez JA: Oxidative stress and inflammation CA-4948 interactions in human obesity. Journal of physiology and biochemistry AZD1390 supplier 2012,68(4):701–711.PubMedCrossRef 30. Leonard B, Maes M: Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci

Biobehav Rev 2012,36(2):764–785.PubMedCrossRef 31. Baumgart DC, Thomas S, Przesdzing I, Metzke D, Bielecki C, Lehmann SM, Lehnardt S, Dorffel Y, Sturm A, Scheffold A, et al.: Exaggerated inflammatory Tideglusib response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease. Clin Exp Immunol 2009,157(3):423–436.PubMedCrossRef 32. Vinderola G, Matar C, Perdigon G: Role of intestinal epithelial cells in immune effects mediated by gram-positive probiotic bacteria: involvement of toll-like receptors.

Clin Diagn Lab Immunol 2005,12(9):1075–1084.PubMed 33. Maassen CB, Claassen E: Strain-dependent effects of probiotic lactobacilli on EAE autoimmunity. Vaccine 2008,26(17):2056–2057.PubMedCrossRef 34. Wahlstrom K, Bellingham J, Rodriguez JL, West MA: Inhibitory kappaBalpha control of nuclear factor-kappaB is dysregulated in endotoxin tolerant macrophages. Shock 1999,11(4):242–247.PubMedCrossRef 35. Kang SS, Ryu YH, Baik JE, Yun CH, Lee K, Chung DK, Han SH: Lipoteichoic acid from Lactobacillus plantarum induces nitric oxide production in the presence of interferon-gamma in murine macrophages. Mol Immunol 2011,48(15–16):2170–2177.PubMedCrossRef 36. Shimosato T, Kimura T, Tohno M, Iliev ID, Katoh S, Ito Y, Kawai Y, Sasaki T, Saito T, Kitazawa H: Strong

immunostimulatory activity of AT- oligo- deoxynucleotide requires a six-base loop with a self-stabilized 5′-C…G-3′ stem structure. Cell Microbiol 2006,8(3):485–495.PubMedCrossRef 37. Pathmakanthan S, Li CK, Cowie J, Hawkey CJ: Lactobacillus plantarum aminophylline 299: beneficial in vitro immunomodulation in cells extracted from inflamed human colon. J Gastroenterol Hepatol 2004,19(2):166–173.PubMedCrossRef 38. Takeda K, Akira S: TLR signaling pathways. Semin Immunol 2004,16(1):3–9.PubMedCrossRef 39. Kondo T, Kawai T, Akira S: Dissecting negative regulation of Toll-like receptor signaling. Trends Immunol 2012,33(9):449–458.PubMedCrossRef 40. Naka T, Fujimoto M, Tsutsui H, Yoshimura A: Negative regulation of cytokine and TLR signalings by SOCS and others. Adv Immunol 2005, 87:61–122.PubMedCrossRef 41. Talaei F, Atyabi F, Azhdarzadeh M, Dinarvand R, Saadatzadeh A: Overcoming therapeutic obstacles in inflammatory bowel diseases: a comprehensive review on novel drug delivery strategies.