At least one of such bleeding. They are HDAC inhibitions usually defined as t ned Dliche bleeding or transfusion was required of them get 159 Were tet. Overall, the proportional increase in gr Eren extracranial bleeding risk during therapy with antiplatelet agents such as the H Half, with no significant difference between the disproportionate increase in the individual risk categories of high fi ve patients was observed. A Hnlicher increase proportionally extracranial hemorrhage in the 2009 meta-analysis of each patient by the Antithrombotic Trialists was obtained Collaboration of six trials of aspirin for primary Rpr Prevention that95% CI, 1.3 1.8. 87 A case-control study with controls The hospital and community has examined the risk of hospitalization for peptic ulcer bleeding with three different therapies for the prevention of aspirin combined. 75 mg, 150 mg and 300 mg: 129 OR were calculated for different doses of aspirin. Other epidemiological studies have shown a dose-response relationship between the prescribing of aspirin and upper gastrointestinal complications, such as Garc a Rodr Guez et al al. 130 It was calculated that 900 of 10,000 bleeding coming from Older people of ulcers. 60 years each year in England and Wales could be linked and attributed to the use of aspirin prophylaxis. 129 If the assumptions of the indirect comparisons are correct, a general shift to lower doses of aspirin would not go away Be the risk, but w Re it be reduced from 300 mg and 30 mg% at a dose of 150 by 40% compared to one dose. 129 The mortality rate in patients who are hospitalized for NSAID-induced upper gastrointestinal bleeding, 5% to 10%. 131 132 The cause widespread belief that enteric-coated aspirin preparations and buffered less likely to cause serious bleeding in the upper gastrointestinal tract in single tablets was evaluated in a multicenter controlled The case. 133 The relative risk of gastrointestinal bleeding than aspirin for plain and enteric-buffered to average daily doses of 325 mg was 2.6, 2.7 and 3.1, respectively. in cans. 325 mg, the relative risk was 5.8 for W Lz and 7.0 for buffered aspirin, there was enough data insufficient to evaluate enteric aspirin at this dose. Conclusions were reached by 133Similar a case-control study using data from the UK General Practice Research Database. Uresekretion 134 suppression of the S Is assumed that the risk of ulcers in regular To reduce sodium use of NSAIDs. In patients which requires an ongoing treatment with NSAIDs Term, sores, or have had. 10 erosions in the stomach or twin Lffingerdarm Omeprazole healed and prevented ulcers better than ranitidine. 135 In these patients, maintenance therapy with omeprazole was associated with a lower recurrence rate and better tolerated than misoprostol. 136 patients with a history of previous bleeding, which took low dose aspirin for 6 months, omeprazole and eradication of H. pylori have with you Hnlichen rates of bleeding, put 137 in combination, although clinically significant differences Cyclophosphamide between the two Pr Not ruled out intervention strategies may be due to the low Stichprobengr e. Two relatively small studies 138.139 challenged earlier guidelines that recommended the use of clopidogrel in patients with major counter-indications, aspirin generally the last significant gastrointestinal bleeding from a stomach ulcer or cant.