It is therefore very important, in order to have protection against tetanus, that all age groups have the universal primary immunization

with subsequent maintenance of adequate antitoxin levels by means of appropriately timed boosters [4, 10]. The clinical manifestations of tetanus which include trismus (lockjaw), dysphagia, neck stiffness and generalized muscular rigidity is due to a powerful neurotoxin (Tetanospasmin) elaborated by the causative bacterium [11]. Four clinical forms of tetanus are recognized and they include generalized, localized, cephalic and neonatal Cell Cycle inhibitor tetanus [9–11]. Spasm related selleck chemicals respiratory compromise, hospital acquired pneumonia and autonomic instability are usually the main causes of morbidity and mortality of this disease [11, 12]. The diagnosis of tetanus is most frequently made on clinical manifestations, rather than on bacteriologic

findings [8–13]. Management of tetanus patients is too demanding, prolonged, and expensive both in terms Erismodegib nmr of materials and manpower [4, 14]. A way to alleviate these problems is by adopting a rigorous tetanus immunization discipline in our community. In Tanzania, like in most developing countries in the world, tetanus is endemic and remains an important health problem especially among the rural farming folks [4]. Tetanus is one of the most common causes of intensive care unit (ICU) admissions at Bugando Medical Centre (a tertiary hospital in Northwestern Tanzania} and is associated with high

morbidity and mortality. This study was undertaken to describe the clinical characteristics and treatment outcome of tetanus patients in our environment and to identify predictors of outcome among these patients. Methods Study setting and design This was a ten-year period retrospective study of patients who presented with tetanus at Bugando Medical Centre between January 2001 and December 2010. Bugando Medical Centre {BMC) is tertiary and teaching hospital for the Weill-Bugando University College of Health Sciences (WBUCHS) and is found in Mwanza city along the shore of Lake Victoria in northwestern Tanzania. It is a 1000-bedded hospital ADP ribosylation factor and serves approximately 13 million people from its neighboring regions namely Mwanza, Mara, Kagera, Shinyanga, Kigoma and Tabora. The hospital has a 12-bed adult and 10-bed paediatric multi-disciplinary Intensive Care Unit (ICU) which is headed by a consultant anesthesiologist and run by trained ICU nurses. Facilities in the unit include multi-parameter patient monitors, 1 defibrillator, syringe pumps, 2 mechanical ventilators and a standby anesthetic machine for emergency resuscitation when required. Oxygen supply is from oxygen concentrators available in the unit and cylinders provided on request from an oxygen bank in the hospital. The unit has one computer for accurate record keeping and documentation.