“Kodamaea ohmeri (K ohmeri) is an emerging opportunistic fungal pathogen that infects an increasing number of immunocompromised patients worldwide. Herein, we present 3 cases of K ohmeri infection in mainland China: 1 case of peritonitis and 2 of fungemia. We review the 32 cases described thus far in the English-language medical literature to investigate the characteristics and treatment
of K ohmeri selleck compound infections and to compare the new cases with those described previously. The increase in infections highlights the significance of K ohmeri as a potential yeast pathogen. Early identification and appropriate antifungal therapy, combined with removal of implanted medical devices, greatly influence clinical outcomes. Further studies are required to determine optimal antifungal regimens and to obtain more comprehensive data on the use of novel antifungal agents such as voriconazole and echinocandins.”
“Objective. This study was to evaluate the relationship
of atherosclerotic renal artery stenosis (ARAS) with extracranial carotid arteries atherosclerosis (ECAS) and intracranial cerebral atherosclerosis (ICAS) in ischemic stroke (IS) patients. CCI-779 chemical structure Methods. This study was a prospective cohort analysis of consecutive patients with IS who had not a history of renal artery stenosis (RAS). Abdominal aortography was performed to screen for RAS after the cerebrovascular diagnostic procedure. Multivariate logistic regression analysis was performed to investigate the association of the clinical variables with significant ARAS (>= 50%). Results. ARAS was identified in 61 (23.1%) of all patients and 34 patients (12.9%) had significant ARAS (>= 50%). ECAS (>= 70%) and ICAS (>= 50%) was found in 66 (25%) and 48 (18.2%) respectively. Patients with ECAS (>= 70%) were more
likely to have significant ARAS than patients without ECAS (28.8% vs 6.2%, p < 0.001). In multivariate analysis, only advanced age (>= 60 years) (OR = 2.84, 95% CI 1.01-7.91) and ECAS (>= 70%) (OR = 5.27, 95% CI 2.396-11.60) were independent risk factors for significant ARAS. Conclusion. Incidental ARAS is a relatively common finding among patients with IS, and there is a close relationship between ARAS and ECAS. Abdominal aortography should be performed to identify selleck chemical ARAS in elderly patients with IS, especially combined with severe ECAS.”
“The purpose of the research was to prepare controlled release glipizide mucoadhesive microspheres with a coat consisting of sodium alginate and a mucoadhesive polymer Carbopol 971P. Orificeionic gelation method by using 3(2) factorial design were investigated with a view to develop mucoadhesive microspheres of controlled release. The resulting microspheres were discrete, free flowing, spherical and multinucleate monolithic type. Microencapsulation efficiency was in the range of 56-88%. Microspheres exhibit good mucoadhesive property in the falling film test.