M OOI, S CHAMBERS, A THOMSON The Canberra Hospital, ACT, Australia Background: EDNAPS, in which propofol is given after the administration of other more traditional sedative agents, has been used for most endoscopic procedures at our hospital since the year 2000. Respiratory compromise related to EDNAPs, including unplanned

endotracheal intubation is much more common with gastroscopies than colonoscopies. It is not clear whether experience with this sort of sedation leads to a fall in unplanned respiratory events. Aims: To assess the safety of EDNAPS for gastroscopies over a 9 year period (2004–2012) and to determine if there is any change in unplanned respiratory events, in particular endotracheal intubation, during this period. Method: A retrospective analysis

Talazoparib clinical trial was performed of a prospectively entered Medical Emergency Team Calls(METCALLs) database of all the activated METCALLs due to respiratory compromise defined as threatened airway, respiratory arrest, oxygen desaturation <90%, respiratory rate >36 breaths or <5 breaths per minute and decreased level of consciousness. Need for endotracheal intubation post gastroscopy was recorded. The database also included patients’ demographics, indication, complications, total sedation administered and clinical outcomes after the METCALLs. Results: Of the 16393 gastroscopies performed using EDNAPS between 1st January 2004 and 1st Nov 2012, there were 18 METCALLs with an age range of 28- 84 years (mean age 61.5: 76.4% males, 23.6% females; 12 were inpatients and 6 outpatients. The ASA Tofacitinib molecular weight score for these patients were II (n = 3), III (n = 13), IV (n = 1) and one patient with no ASA score recorded. Indications for the gastroscopies were gastrointestinal haemorrhage (n = 6: 4 variceal, 2 non-variceal), dysphagia (n = 5), PEG removal (n = 1) and dyspepsia (n = 1). All activated METCALLs were associated with significant oxygen desaturation Histidine ammonia-lyase – range 51–86%. Outcomes: 11 patients made a full recovery and were discharged from the unit. 7 required

endotracheal intubation and went to the Intensive Care Unit (ICU) of whom 6 were emergency cases for upper gastrointestinal bleeding. The other patient, who had previously undergone major facialmaxillary surgery, had undergone PEG removal. One intubation occurred in 2004, 3 in 2005, 2 in 2006 and 1 in 2008 There were 2 deaths in the intubated group – one in 2004 and one in 2005. They were in a 57 yo male, ASA score III, with Child Pugh C liver disease who presented with variceal haemorrhage and was subsequently found to have a large hepatocellular carcinoma. The other occurred in an 86 year old male with ASA score IV who presented with melena due to a malignant gastric ulcer. He was subsequently found to have Stage IV metastatic lung cancer and was palliated and died 8 days post extubation.