Corresponding effect sizes for the difference between treatment groups were and . point by treatment group who reported edema on the self-administer patient-perceived edema question-A B Amlodipine 0 mg Ankle Circumference Placebo Mean Amlodipine 0 mg  mercaptopurine Placebo Baseline Day 5 Day 9 Day 3 Study Day Figure . Mean and mean changes from baseline ankle circumference in this study of segmental bioimpedance for measuring amlodipine-induced pedal edema. March Change in Bioimpedance Clinical Therapeutics Table III. Self reports of edema using the patient-perceived edema questionnaire with amlodipine or placebo in this study of segmental bioimpedance for measuring amlodipine-induced pedal Baseline Week Week Week Perceived Edema Amlodipine Placebo Amlodipine Placebo Amlodipine Placebo Amlodipine Placebo Very little Moderate Extreme naire.

None of the participants reported edema at base-li and participants treated with  Biochanin A amlodip-ine 0 mg and participants treated with placebo reported edema at any time during the weeks of treatment. The differences between treatment groups in the severity and duration of edema were not signi ant. After and weeks of dosi participants with perceived edema No statistically signi ant difference in the clinical as-sessment of pitting was found between amlodipine 0 mg and placebo after or weeks of treatment. A statistically signi ant increase from baseline in pitting sco howev was found with am-lodipinepared with placebo after weeks of treat-ment.

Using either water displacement or bioimped-an clinical assessment of pitting was  Cidofovir 113852-37-2 calculated to be in the amlodipine 0-mg group also had the largest moderately sensitive after weeks mean increases in water displacement after 0 , and g, respectively) and the largest weeks of treatment with amlodipine. Speci ity de-decreases in segmental bioimpedance . Spearman rank corre-Figure shows the median changes from baseline in lation tests identid potential correlations between treatment and perceived ede duration of perceived edema and degree of swelli and duration of per-water displacement versus the median changes from baseline in bioimpedance in each participant at week , with each participant with a pitting score of at least ceived edema and limitations on normal activity; no trace in both ankles clearly indicated. statistically signi ant correlations were found with any of the tests. The correlations between change from  buy epigallocatechin baseline in water displacement and change from baseline in bio-Table IV shows the number of ankles for which impedance were and , at weeks , pitting was detected by time point by treatment group. , and , respectively. There was no association be-Table IV.

Clinical assessment of ankle pitting with amlodipine or placebo in this study of segmental bioimpedance for measuring amlodipine-induced pedal edema. Values are number of ankles. Baseline Week Week Week Pitting Score Trace Amlodipine Placebo Amlodipine Placebo Amlodipine Placebo Amlodipine Placebo Volume 4 Number D.A. Schoeller Amlodipi no pitting Place no pitting Amlodipi clinical pitting Place clinical pitting  anatomy Bioimpedance Figure . Correlations between median water dis-placement and median bioimpedance at 0 k overlaid with clinical assessment of pitting at week.