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Authors’ contributions GR is the group leader and this work represents one of the research lines pursued in his laboratory; he directly supervised the experimental work. MC carried out most of the experimental work. GG and MC contributed with stimulating suggestions and encouraging discussions.”
“Background Lung cancers used to be categorized into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). About 13%-15% of all lung cancers worldwide are SCLC. As a type of malignant tumor, SCLC shows many general clinical manifestations such as early metastasis, frequent recurrence and tendency toward poor response to chemotherapy. Some authors [1, 2] have previously demonstrated that these clinical manifestations are partially the result of a series of biological changes that occurred in tumor cells when responding to hypoxia. In other words, the hypoxic microenvironment promotes the malignant development of the tumor.