Results A-1210477 in vitro are presented as mean ± SD. * =  p <0.05   Pre-race Post-race Absolute selleck products change Percent change Haemoglobin (g/dl)

14.8 ± 0.7 15.0 ± 0.9 + 0.2 ± 0.6 + 1.2 ± 4.3 Haematocrit (%) 43.9 ± 2.5 43.7 ± 2.9 – 0.2 ± 2.6 – 0.4 ± 5.8 Serum sodium (mmol/l) 138.9 ± 1.4 140.0 ± 2.9 + 1.1 ± 2.9 + 0.8 ± 1.8 Serum potassium (mmol/l) 4.4 ± 0.4 4.4 ± 0.4 + 0.0 ± 0.5 + 0.7 ± 12.0 Serum creatinine (μmol/l) 76.3 ± 9.2 94.5 ± 19.1 + 18.2 ± 19.6 * + 25.2 ± 30.0 Serum urea (mmol/l) 5.9 ± 1.1 9.0 ± 1.1 + 3.1 ± 1.2 * + 57.6 ± 27.6 Serum osmolality (mosmol/kgH2O) 296.6 ± 2.9 304.6 ± 6.0 + 8.0 ± 6.3 * + 2.7 ± 2.1 Urine specific gravity (g/ml) 1.013 ± 0.006 1.026 ± 0.005 + 0.013 ± 0.007 * + 1.33 ± 0.76 Urine osmolality (mosmol/kgH2O) 531.7 ± 271.2 836.5 ± 196.3 + 304.8 ± 201.3 * + 94.5 ± 88.9 Fractional sodium excretion (%) 1.32 ± 0.76 0.39 ± 0.27 – 0.93 ± 0.65 * – 66.6 ± 23.1 Fractional urea excretion (%) 54.2 ± 10.9 29.2 ± 11.7 – 25.0 ± 14.2 * – 44.6 ± 23.1 Creatinine clearance (ml/min) Alvocidib 116.5 ± 23.4 91.6 ± 15.5 – 24.9 ± 25.7 * – 19.3 ± 16.0 Potassium-to-sodium ratio in

urine (ratio) 0.54 ± 0.40 4.41 ± 4.96 + 3.87 ± 4.88 * + 996 ± 1,504 Transtubular potassium gradient (ratio) 22.4 ± 17.8 100.1 ± 60.3 + 77.7 ± 59.2 * + 936 ± 1,230 Correlations between fluid intake and changes in body composition Fluid intake was unrelated to the decrease in body mass (p >0.05). The change in body mass was not associated with the change in serum [Na+] (p >0.05). The change in body mass was related to both post-race serum [Na+] (Figure 2) and post-race serum osmolality (Figure 3) (p <0.05). The decrease of the volume of the lower leg was unrelated to fluid intake (p >0.05). Fluid intake was neither related to the changes in the thickness of adipose subcutaneous see more tissue nor to the changes in skin-fold thicknesses (p >0.05). Sodium intake was not related to post-race serum [Na+] (p >0.05). Post-race serum [Na+] was unrelated to both the change in the potassium-to-sodium ratio in urine and TTKG (p >0.05). The increase in serum urea was not related to the increase in serum osmolality (p >0.05). The change in serum urea was unrelated to the change in skeletal muscle

mass (p >0.05). The change in the thickness of the adipose subcutaneous tissue at the medial border of the tibia was significantly and positively associated with the change in creatinine clearance (r = 0.58, p = 0.025). The non-significant changes in skin-fold thicknesses were neither related to overall race time nor to the split times (p >0.05). Figure 2 The change in body mass was significantly and negatively related to post-race serum [Na + ] ( n  = 15) ( r  = −0.52, p  = 0.045).