Such a construction project is the goal of RDoC. If the project is successful, future

versions of the DSM and ICD – perhaps not even DSM-6, but DSM-7 – will be informed by the findings that emerge from RDoC-guided research. The process will not be easy or short, but already the Institute has seen an accelerating number of Inhibitors,research,lifescience,medical RDoC-themed grant applications. Time will tell whether such interest is the harbinger of a paradigm shift in how the research and practice community conceptualizes mental disorders, but at the least, the RDoC project seems likely to generate new perspectives regarding the relationships of brain and behavior with respect to mental illness. Notes The authors report no financial conflicts of interest.
Unfortunately, researchers have been somewhat too creative in their definitions, with over a dozen possibilities being suggested in the literature. Most investigators seem to favor a two-criterion definition: an idea or response is said to Inhibitors,research,lifescience,medical be creative Inhibitors,research,lifescience,medical if it is (i) novel or original;

and (ii) useful, adaptive, or functional.9-10 The drawback to this definition is that it is perfectly feasible for an idea to be novel and useful without being necessarily surprising. Algorithmic solutions are of this nature. Because the cognitive processes supporting Inhibitors,research,lifescience,medical algorithmic problem solving are quite unlikely to be similar to the processes supporting more heuristic problem solving, it is advisable to add a third criterion, namely, surprising11 or “nonobvious” as determined by the standards established by the United States Patent Office.12 This

three-criterion definition has several repercussions, including the increased necessity of engaging in blind-variation and selective-retention (BVSR) processes.13 Yet, from the standpoint of this brief note, the main implication is that creativity must be separated from both general intelligence and domain-specific expertise, Inhibitors,research,lifescience,medical neither of which can produce anything PF01367338 surprising because each is dedicated to converging on the single most correct response. Convergent thinking seldom induces surprise. Indeed, the convergent thinking witnessed in the application AG-490 in vitro of general intelligence and domain-specific expertise is designed for different kinds of problems than for divergent thinking and other processes seen in creativity. A nice illustration is the distinction between reasonable problems that “can be reasoned out step by step to home in on the solutions” (eg, anagrams and crossword puzzles) and unreasonable problems that “do not lend themselves to step-by-step thinking. One has to sneak up on them,” eg, all true insight problems).