The GRADE approach to grading quality of evidence about diagnostic tests and strategies. Allergy 2009, 64:1109–1116.PubMed 4. Moore LJ, Moore FA, Jones SL, Xu J, Bass BL: Sepsis in general surgery: a deadly complication. Am J Surg 2009,198(6):868–74.PubMed 5. Moore LJ, Moore FA, Todd SR, Jones SL, Turner KL, Bass BL: Sepsis in general surgery: the 2005–2007 national surgical quality improvement program perspective. Arch Surg 2010,145(7):695–700.PubMed 6. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G,

Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL, EGFR inhibitor International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Selumetinib Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine;

Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine: Surviving Metalloexopeptidase Sepsis Campaign: international guidelines for management of severe sepsis and

septic shock: 2008. Crit Care Med 2008,36(1):296–327.PubMed 7. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ, American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidlines for the use of innovative therapies in sepsis. Chest 1992, 101:1644–1655.PubMed 8. Calandra T: Pathogenesis of septic shock: implications for prevention and treatment. J Chemother 2001,13(Spec No 1(1)):173–80. ReviewPubMed 9. Bochud PY, Calandra T: Pathogenesis of sepsis: new concepts and implications for future treatment. BMJ 2003 326:262–6. 10. Dinarello CA: Proinfiammatory and anti-infiammatory cytokines as mediators in the pathogenesis of septic shock. Chest 1997, 112:321S-329S.PubMed 11. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M, Early Goal-Directed Therapy Collaborative Group: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Eng J Med 2001, 345:1368–1377. 12. Vincent JL, Biston P, Devriendt J, Brasseur A, De Backer D: Dopamine versus norepinephrine: is one better? Minerva Anestesiol 2009,75(5):333–337.PubMed 13. Hollenberg SM: Vasopressor support in septic shock.