The QTc interval has been reported to be increased and to be associated with high-risk ventricular arrhythmias and sudden death (2). Although renal transplantation improves survival, cardiovascular morbidity and Kinase Inhibitor Library molecular weight mortality still remain as a significant problem compared with nonrenal populations (3). The aim of this study is to evaluate the association between the QTc interval changes and arterial stiffness in kidney transplant recipients. Methods: One hundred kidney transplant recipients from our renal transplant outpatient clinic were enrolled

into the study. All patients were evaluated for their standard clinical (age, gender, duration of hemodialysis, post-transplant time), biochemical selleck antibody inhibitor parameters. Anthropometric and body composition analyses were performed for all patients. Body compositions were analyzed

by using the Body Composition Analyzer (Tanita BC- 420MA). PWv was determined from pressure tracing over carotid and femoral arteries using the SphygmoCor system. Pre- (retrospectively) and post-transplant electrocardiographic (ECG) evaluations were performed. Each QT interval was corrected for the patient’s heart rate using Bazett’s Formula. A QTc interval greater than 440 ms was considered abnormally prolonged. Results: After renal transplantation maxQTc intervals (456.7 ms to 414 ms) and QTdc (54 ms to 34 ms) of all patients were significantly decreased. In post transplantation period, patients with high QTc intervals had significantly higher PWv (p:.009) (Table 2) and higher serum CRP levels (p:.001) than patients with QTc < 440 ms. Patients with PWv ≥ 7 m/s had significantly higher maxQTc interval decline than patients with PWv < 7 m/s (p: –.05, r: –.206). Conclusion: High QTc interval after renal transplantation could 3-mercaptopyruvate sulfurtransferase be a predictor of arterial

stiffness in renal transplant recipients. Electrocardiographic evaluation is seem to be a cheap and reliable way to detect arterial stiffness. CHEMBO CAROLINE, MANLEY PAUL, DITTMER IAN Dept Renal Medicine, Auckland Hospital, NZ Introduction: Renal transplantation remains the best form of renal replacement therapy. The prevalence of hepatitis B infection in the dialysis population is declining but remains high in certain populations. The outcomes of renal transplantation in hepatitis B surface antigen patients has previosuly been reported to be poor. We report the outcomes in such patients who received renal transplants at our centre from 1981–2011. Methods: All patients transplanted from 1981 to 2011 who were HepB surface antigen positive prior to transplant were included in the analysis. Local databases and hospital records were reviewed for outcomes. Results: 20 patients were identified. They were predominantly male, of Maori ethnicity and received deceased donor organs. Mean age was 40 years (19–59). The majority of patients received lamivudin post-transplant.