The scale was shown to be one-dimensional through factor analysis (explained variance = 72%). A cut-off point of 10 showed adequate values of sensitivity (86.8%) and specificity (93.4%), with AUC being statistically significant [AUC = 0.957-0.985); p < 0.001]. The scale significantly correlated with HAM-A (0.852,

p < 0.001), HADS (anxiety domain, 0.903, p < 0.001), and WHO-DAS II (0.696, p > 0.001).

Limitations: Elderly people, particularly Smoothened Agonist those very old, may need some help to complete the scale.

Conclusion: After the cultural adaptation process, a Spanish version of the GAD-7 scale was obtained. The validity of its content and the relevance and adequacy of items in the Spanish cultural context were confirmed.”
“The effects of transjugular intrahepatic portocaval shunt ALK inhibitor (TIPS) on the survival of grafts and patients after liver transplantation (LTx) have only been documented in small series and with only a comparative description

with non-TIPS recipients. We evaluated 61 TIPS patients who had a subsequent LTx and compared these with 591 patients transplanted with cirrhosis without TIPS. Pretransplant characteristics were similar between groups. Graft survival at 1, 3 and 5 years post-LTx was 85.2%, 77% and 72.1% (TIPS) and 75.3%, 69.8% and 66.1% (controls). Patient survival at the same points was 91.7%, 85% and 81.7%, respectively (TIPS) and 85.4%, 80.3% and 76.2% (controls). Cox regression showed the absence

of TIPS pre-LTx, transfusion of > 5 units of blood during LTx, intensive HSP tumor care unit (ICU) stay post-LTx > 3 days and earlier period of transplant to be significantly associated with a worse patient and graft survival at 1 year. Migration of the TIPS stent occurred in 28% of cases, increasing the time on bypass during LTx, but was not related to graft or patient survival. TIPS may improve portal supply to the graft and reduce collateral flow, improving function. This may account for the improved adjusted graft and patient survival by Cox regression at 12 months. Long-term survival was not affected.”
“Background: Although fatty acids are known to be important in various skin functions, their roles on photoaging in human skin are poorly understood.

Objective: We investigated the alteration of lipid metabolism in the epidermis by photoaging and acute UV irradiation in human skin.

Methods: UV irradiated young volunteers (21-33 years, n = 6) and elderly volunteers (70-75 years, n = 7) skin samples were obtained by punch biopsy. Then the epidermis was separated from dermis and lipid metabolism was investigated.

Results: We observed that the amounts of free fatty acids (FFA) and triglycerides (TG) in the epidermis of photoaged or acutely UV irradiated human skin were significantly decreased.