The study’s aim was to compare results obtained with these two devices.

Methods: Prospective observational study of transfemoral prosthesis implantation performed at our center.

Results: Of the 76 patients (age 83 +/- 6 years, 63% female, logistic EuroSCORE 18 +/- 9) included, 50 were assigned the ES and 26 the MCV device. There was no difference between the groups in age, sex, functional class, valve area, associated conditions, or EuroSCORE. Implantation was successful in 84%

of the ES group and 100% of the MCV group (P = .04). There were three cases of tamponade, two aortic dissections and one valve malposition in the ES group. The two groups had similar vascular access complication rates (26% vs. 23%; P = NS), but pacemaker need was greater with the MCV (10% vs. 39%; P = .003). Mortality Entinostat inhibitor rates at 30 days were 12% and 20% (P = NS) in the ES and MCV groups, respectively, and at 1 year, NU7441 24% and 20% (P = NS), respectively. After a follow-up of 367 +/- 266 days in the ES group and 172 +/- 159 days in the MCV group, three patients died. Clinical improvement was maintained in other patients and no echocardiographic changes were observed.

Conclusions: In-hospitalmortality, the complication rate and medium-term outcomes were similar

with the two devices. The only difference observed was a higher implantation success rate with the MCV, although at the expense of a greater frequency of atrioventricular block. (C) 2010 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S.L. All rights reserved.”
“The volume of research undertaken on the genetic susceptibility of inflammatory bowel diseases has been tremendous. International collaborative efforts which initiated in 1997 and have not stopped since, led to the identification at present of more than 100 IBD risk loci. Yet, only 25% of the genetic variance is explained. It is hypothesized that rare variants, other forms of genetic variation (copy number

variation), as well as gene-gene and gene-environment interactions, explain the missing heritability. GDC-0941 in vitro From all genes identified, the pattern recognition receptor NOD2/CARD15 is still the most understood at present. The field of IBD genetics has translated itself so far in identifying pathways important for disease pathogenesis (autophagy, Th17/IL23, pattern recognition receptors and innate immunity, barrier integrity), some of which have promising therapeutic consequences. Second, although genetic testing will most likely have no or a very limited role in diagnosing patients, it is anticipated that genetic markers will be implemented in an integrated prognostic approach. Efforts to predict disease course and response to therapy have shown interesting results. (C) 2011 Elsevier Ltd. All rights reserved.