The work conducted in the author’s laboratory was supported by a Grant-in-Aid for Scientific Research on Priority Areas (C) (2), #19592309 from the Ministry of Education, Culture, Sports, Science and Technology of Japan. “
“Over the last decade, the use of dental adhesives for bonding restorations and fixed partial dentures has increased substantially. This

trend is mainly attributed both to improvement in properties as well as bonding durability of adhesive systems. Current bonding and priming agents contain various functional monomers especially designed for intraoral application, including carboxylic acids, acid anhydrides, phosphates, silanes, and thiones. Silver–palladium–copper–gold (Ag–Pd–Cu–Au) alloys with 12% gold are extensively used in Japan as cast restorations, fixed partial dentures, and framework of removable

dentures. In addition, Regorafenib price a number of bonding systems for noble metal alloys have been developed. This paper reports on the bonding systems applicable for noble metal alloys, techniques for seating restorations and fixed partial dentures (FPDs) made of Ag–Pd–Cu–Au HDAC inhibitor alloys, and clinical performance of bonding systems. Carboxylic acids, acid anhydrides, and phosphates are being used for bonding tooth substrates, base metal alloys, alumina and zirconia ceramic materials. However, they are incapable of bonding noble metal alloys. The use of thione or thiol monomers has been proved effective for bonding noble metal alloys. Mori and Nakamura [1] reported 6-(4-vinylbenzyl-n-propyl) amino-1,3,5-triazine-2,4-dithiol

(VTD or VBATDT) for use as a priming agent for copper. Using the VTD dithiol-dithione tautomer and tri-n-butylborane (TBB)-initiated resin, Kojima et al. [2] reported durable bond of VTD to noble metal alloys. Two sulfur-based functional monomers were thereafter synthesized. One is 6-methacryloyloxyhexyl-2-thiouracil-5-carboxylate (MTU-6) [3], and the other is 10-methacryloxydecyl 6,8-dithiooctanoate (MDDT) [4]. Four representative priming agents, all of which consist of single liquid, are currently Ribonucleotide reductase available (Table 1); V-Primer (VTD), Alloy Primer (VTD), Metaltite (MTU-6), and M.L. Primer (MDDT). Among the functional monomers shown in Table 1, VTD, MTU-6, and MDDT contain sulfur, and considered to be effective for bonding noble metal elements, copper, and noble metal alloys, whereas two acidic monomers, 10-methacryloyloxydecyl dihydrogen phosphate (MDP) [5] and 6-methacryloxyhexylphosphonoacetate (MHPA) [6], are considered to be effective for bonding base metal alloys and titanium. Fig. 1 shows the structural formulae of adhesive functional monomers. The single liquid primers eliminated the need for surface modification procedures, and are being successfully used for seating FPDs, cast restorations, and dowel cores made of noble metal alloys.