Therefore, HBsAg is not a reliable marker in monitoring the effectiveness of treatment in patients with oral antivirals. Key Word(s): 1.

Hepatitis B; 2. HbsAg; 3. HBV-DNA; 4. Interferon; Presenting Author: KAMRANB. LANKARANI Additional Authors: FARIBORZ GHAFFARPASAND, MOJTABA MAHMOODI, Cabozantinib ic50 MEHRZAD LOTFI, NIMA ZAMIRI, SEYED TAGHI HEYDAR, MOHAMMAD KAZEM FALLAHZADEH, NAJMEH MAHARLOUEI, MEISAM BABAEINEJAD, SOHEILA MEHRAVAR Corresponding Author: KAMRANB. LANKARANI Affiliations: Health Policy Research Center, Shiraz University of Medical Sciences; Health Policy Research Center, Shiraz University of Medical Sciences; Health Policy Research Center, Shiraz University of Medical Sciences; Health Policy Research check details Center, Shiraz University of Medical Sciences; Health Policy Research Center, Shiraz University of Medical Sciences; Health Policy Research Center, Shiraz University of Medical Sciences; Health Policy Research Center, Shiraz University of Medical Sciences; Health Policy Research Center, Shiraz University of Medical Sciences; Health Policy Research Center, Shiraz University of Medical Sciences Objective: The prevalence and associated

risk factors of NAFLD may vary in different geographical region. Population based studies on prevalence and risk factors of NAFLD in Iranian population are few. The main aim of this population-based study was to determine the prevalence of NAFLD and its risk factors in a sample of adult Iranian population of southern Iran. Methods: This was a cross-sectional study being performed in Shiraz, southern Iran during a 10-month period from November 2010 to September 2011 through cluster random sampling of Iranian general population in Shiraz region. All individuals underwent anthropometric and blood pressure measurements and thorough medical history and physical examinations. Laboratory measurements included fasting blood glucose (FBS), lipid profile, complete blood count (CBC) and liver

function tests. NAFLD was diagnosed by transabdominal ultrasonography. Results: Overall we included 819 subjects in this study among which there were 340 males (41.5%) and 479 females (58.5%) with the mean age of 43.1 ± 14.1 上海皓元 years. NAFLD was diagnosed in 176 (21.5%) subjects. Patients with NAFLD were significantly older (p < 0.001), had higher proportion of male gender (p = 0.004) and had higher BMI (p < 0.001). They also had higher prevalence of hypertension (p < 0.001), high FBS (p < 0.001), high cholesterol (p = 0.026), high triglyceride (p < 0.001) and high waist circumference (p < 0.001). Taking all these together, patients with NAFLD had significantly higher prevalence of metabolic syndrome when compared to healthy subjects (p < 0.001). Conclusion: The prevalence of NAFLD in this group of Iranian adult general population is 21.5%. NAFLD in Iranian population is associated with male gender, old age, obesity, and features of metabolic syndrome. Key Word(s): 1. NAFLD; 2. Prevalence; 3.