This study population was contacted by mail approximately eight weeks post loss with an invitation to participate in the study along with a self-report questionnaire. Respectful reminders were sent by mail to non-responders after two weeks. Participants Nine hundred fifty two bereaved were contacted, 838 sampled through the CPR and 114 via the palliative home care team (see Figure ​Figure1).1). Forty (40) individuals were excluded from the study due to reasons such as Inhibitors,research,lifescience,medical death, hospitalisation and dementia. Four hundred sixteen individuals (46%) agreed to participate in the study. Thirty-three (33) cases were excluded from the analyses due to more than 15% missing items. Thus, at baseline (T1), 383 of the eligible bereaved

people participated in the study. Due to non-response of 104 participants at the first follow-up (T2) data from 276 participants was analysed for this study. Figure 1 Flowchart of participants analyzed in the study. Paclitaxel microtubule Measures Data collection was based on self-report questionnaires. Inhibitors,research,lifescience,medical Based on findings in earlier studies on CG, we wanted to investigate depression, PTSD, coping style, social support and personality variables as possible risk factors [6,13]. The questionnaire contained

the following standardized scales and single items: Inhibitors,research,lifescience,medical Inventory of Complicated Grief-Revised (ICG-R) [6]; The Beck Depression Inventory (BDI)[15]; The Harvard Trauma Questionnaire-Part IV (HTQ-16)[16]; The Crisis Support Scale (CSS) [17]; Coping Style Questionnaire (CSQ) Inhibitors,research,lifescience,medical [18]; Sense of Coherence (SOC) [19]; Satisfaction with Life Scale (SWLS) [20]; The NEO Personality Inventory (NEO-PI-R)[21]. The baseline questionnaire also contained socio-demographic questions on education,

years of marriage and number of children and a number of single items on distress and meaning of life (see later). Inventory of complicated Grief-Revised (ICG-R) In this study CG was measured with the ICG-R. The ICG-R is a modified and shorter version of the original Inventory of Complicated Grief (ICG), which consisted of 19 items [6]. The ICG was developed to assess maladaptive symptoms of loss and contains all symptoms proposed for the Inhibitors,research,lifescience,medical PGD www.selleckchem.com/products/ganetespib-sta-9090.html diagnosis [7}. The ICG-R is based on 15 questions with a 5-point Likert-scale, a functional criterion and a duration criterion of six months. Due to the duration Dacomitinib criterion of six months, the ICG-R was administered at six months as the earliest measuring point. The version of the ICG-R administered in this study, had been used in an earlier Danish study, where it had proven highly reliable with Cronbach's α>0.94; and a mean inter-item correlation of 0.52 [22]. The results of the ICG-R served as the gold standard in this study. We used the cut off point of the 20% most distressed based on a syndromal level as initially suggested by the authors of the scale [6]. Using this method the cut off point in the Danish population was set to an ICG-R score of 43 and above. Fifty four (19.