ETED not received much Topoisomerase I attention. Available data suggest that the toxicity of t of chemicals other parents Are similar and the toxicity of t from its degradation products appeared Similar to each other. Due to significant differences in the toxicity of t and toxicokinetics profiles of profile data that was additionally USEFUL data direct chemical degradation products as unreliable mothers, precious metals,. The Panel concluded that the toxicity of t gr mothers of chemicals He is than the toxicity of t of degradation products of direct exposure. This conclusion is supported by the results of the comparative toxicity of t for acetochlor and alachlor from their degradation products and metolachlor and its degradation products. Moreover, this conclusion with the results of recent evaluations in the United States EPA. For these reasons, the Committee discussed the development of reference doses for degradation products directly as a better alternative than the use of chemicals as a substitute for parental toxicity t. The main conclusions in relation to candidate critical effects from animal studies on the degradation products are described in the n Next section. 3.1.1. Decreased K Body weight and subchronic toxicity studies of chemicals showed parents acetochlor and alachlor, the Ver Change of the K Rpergewichts an important effect of these chemicals. The NOAEL and LOAEL for decreased K Body weight of chemicals and degradation products for mothers are rats in the pr Sentierten numbers. 2a and 2b. Parents, such as chemicals, was Ver Changes of K Rpergewichts an h More often finding in the studies of 28 and 90 days are available degradation products. There TH-302 918633-87-1 was a study of body weight dose-response data for K, K Body weight or weight gain led adapted and correlated the results with respect to feed intake and feed efficiency. Food consumption was reported in grams of food consumed per rat per day. Feed conversion was calculated as the K Recorded body weight of rats recovered per 100 g of food. Food utilization is complicated by the FA One of which is based on the dry weight to wet weight of feed, live weight of the carcass, biological reactions, etc. based business Protected. The evaluation of the K Rpergewichts and increased food intake Ltlichen metrics are complicated by the inclusion of palatability. The interaction between K body weight, Food intake, and palatability was weighed in order to make judgments about the adversities of Changes of K Rpergewichts for the degradation products. The data show that the decrease in the K Rpergewichts were a side effect for some treatment related 90 studies per day. In this analysis, a dose- Independent decrease in K Rpergewichts by 10% was considered an adverse event. Group mean K Body weight over time for the degradation products is shown in FIGS. 3a-3e and a summary of the study design and dosing schedule for each of the subchronic studies for the four degradation products in Table 1 is provided. A 90-t Pendent study and a study on drinking water 91 days food was available for alachlor ESA. In the 90-t Pendent study of the di Tetischen high doses, 788 mg / kg per day and 926 mg / kg per day were considered the NOAEL. Effects at the LOAEL were minimal Ver Changes of K Rpergewichts and no Change in the Etoposide consumption of food. Data on the use of food were not provided in the study. In the study of drinking water for alachlor ESA, there was a decrease of 5% K Body weight at week 13 in both sexes at the high dose. The relevance of the first observations reduces the K Body weight in the high dose wa.