We feel that it is unlikely that the structural and functional differences in these regions between the SLI group and the other two groups are due to age differences, but further study using larger samples is warranted. The structural and functional investigations into SLI provide useful insights into the neural differences which may underpin the language difficulties observed behaviourally. There Selleck HKI-272 is clear evidence of atypical structure and function in the left inferior frontal and superior temporal areas known to be involved in language production and

comprehension. Subcortical components including the caudate nucleus and putamen are also implicated, most likely due to their involvement with motor response

planning, selection, and preparation. Future investigations Endocrinology antagonist should aim to elucidate the developmental trajectories of structure and function, functionally assessing both receptive and expressive components independently. Between-group consideration of the task demands may also be important, attempting to minimise any influence of task difficulty. Furthermore, considering both left and right hemisphere specialisation and organisation, assessing prosodic speech aspects and regional connections will provide useful insights. We wish to thank all our participants for their continued cooperation with our research. We would also like to thank Marko Wilke for his friendly support with the LI-toolbox. This research was funded by the Medical Research Council UK G0400298 to KEW and the Wellcome Trust Programme Grant Nos. 053335/Z/98/Z and 082498/Z/07/Z to DVB. “
“There are a number of topographical structures in the Baltic

which, despite their small dimensions, play an essential role in the circulation and water exchange of this sea. The generally adopted division of the Baltic Sea is therefore based on bottom topography: this highlights the basins with clearly defined hydrographical parameters (Fonselius, 1969, Mikulski, 1987, HELCOM, 1990 and Omstedt, Glutamate dehydrogenase 1990). i.e. the Gulf of Bothnia, Bothnian Sea, Gulf of Finland, Gulf of Riga, Baltic Proper, Danish Straits and Kattegat. In terms of volume and surface area, the largest basin is the Baltic Proper (more than 50% of the volume and surface area of the Baltic Sea), which in turn consists of three smaller basins – the Bornholm Deep, Słupsk Furrow and Gdańsk Deep. The Gulf of Finland has no distinctive topographic sill; it is separated from adjacent basins by a strong hydrological front. Owing to the large river discharge and inflows of highly saline oceanic waters (Matthäus & Franck 1992), the Baltic Sea is characterized by very large horizontal and vertical salinity gradients. These contrasting processes, as well as solar radiation and heat exchange with the atmosphere, lead to the formation of a complex and variable thermohaline stratification.