E drug short half-life, and the fact
that an optimum biological and therapeutic dose has not yet been defined. The sorgf insurance valid selection of patients may also r Key in maximizing Effektivit WZ3146 t These anti-angiogenic agents. Other targeted therapies mTOR inhibitors Pr Clinical studies show that mTOR inhibitors used alone in most tumors and cytotoxic drugs may stabilize the clinical disease. Data from clinical trials, which was to look as monotherapy everolimus not impressive. A phase II study comparing t Glicher administration of w Chentlichen doses of everolimus monotherapy in patients with recurrent metastatic breast cancer found a low response rate, no correlation of the biological response, despite the favorable trends in earnings in the ER positive and negative breast cancer HER.
However, the toxic effects of drugs with modest encourage drug combination studies are examined two studies under way connected to the use of Afinitor in the treatment of TNBC. As with all other treatments targeted marker of response to treatment as mTOR are crucial in Syk Inhibitors the selection of patients. The cancer patients showed decreased PTEN, activated mTOR activation or PIK high p were reported in order to benefit the most from this class of drugs, but should expand the work in this area. R IGF Several Phase I studies were rpern several humanized monoclonal TKI and was safe and well tolerated in patients with solid tumors. Data from a study of tissues by Witkiewicz and colleagues have shown that IGF R is overexpressed and amplified in TNBC samples.
High IGF-R expression was significantly correlated with lymph node metastasis negative and ngeren in patients aged less than year, with an L Survive. IGF-R tyrosine kinase Cathedral ne Insulin receptor inhibitor BMS showed activity t in TNBC are ongoing studies and the effectiveness of this class of targeted treatment of breast cancer. NCT inhibition of the androgen receptor is an ongoing study to evaluate the use of bicalutamide, uses an anti-androgen, for prostate cancer, in the treatment of treating HRnegative the AR-positive breast cancer. Bicalutamide was tolerated in this population and a vorl INDICATIVE analysis showed disease stabilization in ER PR negative, positive with AR AR inhibition. Studies heat shock protein inhibitors and clinical assess AUY Hsp inhibitor IPI, but only in the emergency department and its positive disease.
That the center of this class in vivo and in particular, it remains to be seen effectively TNBC. Conclusion The tumor biology TNBC, basal like breast cancer, mutated BRCA machines and low Krankheitsaktivit t claudine is both specific and vielf validly. W While herk Mmliche chemotherapy can be effective for the treatment of women with TNBC and the base, as the disease, it is clear that this group of diseases is heterogeneous in nature and should not be classified under other. New therapies to DNA Sch To the players angiogenic structures of tubulin, the protein mTOR, IGF R, AR, and show promise in HSP studies at an early stage, but their clinical performance has not yet proven. Undoubtedly, a large part of it. At is focused on generating more specific terminology to identify the optimal patient population for each treatment S ugerzellen Genotoxic stress under constant are both endogenous and exogenous sources.