01) but did not reach statistical significance compared to the water group. Conclusion: The use of simethicone given before endoscopy provided better mucosal visibility requiring lesser this website volume of water flushes and shorter procedure time. Key Word(s): 1. Simethicone; 2. mucosal visibility; 3. endoscopy Presenting Author: OSAMU DOHI Additional Authors: ATSUSHI MAJIMA,

YURIKO ONOZAWA, TOMOKO KITAICHI, YUSUKE HORII, KENTARO SUZUKI, AKIRA TOMIE, KAZUHIRO KAMADA, NOBUAKI YAGI, YUJI NAITO, YOSHITO ITOH Corresponding Author: OSAMU DOHI Affiliations: Kyoto Prefectural University of Medicine, Kyoto Prefectural University of Medicine, Kyoto Prefectural University of Medicine, Kyoto Prefectural University of Medicine, Kyoto Prefectural University of Medicine, Kyoto Prefectural University of Medicine, Kyoto Prefectural University of Medicine, Murakami Memorial Hospital Asahi University, Kyoto Prefectural University of Medicine, Kyoto Prefectural University of Medicine Objective: Blue LASER Imaging (BLI) is a new image-enhanced endoscopy with a laser light source developed for narrow-band light observation. The aim of this study is to evaluate the usefulness of BLI for the diagnosis of early gastric cancer. Methods: We prospectively analyzed 110

gastric lesions that were examined with both the conventional endoscopy with white-light image (C-WLI) observation and magnifying endoscopy with BLI (M-BLI) observation at Kyoto Selleckchem NVP-BGJ398 Prefectural University of Medicine between November 2012 and May 2014. The diagnostic criteria of gastric cancer using C-WLI were both an irregular margin and an irregular mucosal area. The diagnostic criteria of gastric cancer using ME-BLI were an irregular microvascular (MV) pattern and/or irregular microsurface (MS) many pattern with the demarcation line evaluated by VS classification system. The lesions were taken biopsies after M-BLI observation following C-WLI observation. We evaluated the correlations between

the diagnosis of M-BLI and that of histopathology, compared with the correlations between the diagnosis of C-WLI and that of histopathology. Results: We analyzed 110 detected lesions (23 cancers and 87 noncancers). The accuracy, sensitivity and specificity of high confidence M-BLI diagnoses were 93.6, 91.3 and 94.3%, respectively. Most of the false positive cases were depressed mucosal lesions with the histopathological diagnosis of regenerative gland in pyloric/fundic mucosa with inflammatory cell infiltration. On the other hand, the accuracy, sensitivity and specificity of C-WLI diagnoses were 88.1, 56.5 and 96.6%, respectively. Conclusion: M-BLI was useful for the diagnostic accuracy and sensitivity of early gastric cancer compared with C-WLI. Key Word(s): 1. BLI; 2. VS classification; 3.