4 Albendazole is effective treatment for infection with Encephalitozoon species but is less effective for Enterocytozoon infections. Fumagillin is considered more effective for Enterocytozoon infections but it has significant bone marrow toxicity. To our knowledge, only 21 cases of disseminated microsporidiosis have been reported worldwide in non-HIV, solid organ transplant and bone marrow transplant recipients.5E. bieneusi was the most commonly isolated microsporidia and disseminated disease with Encephalitozoon species in non-HIV-infected,
transplant recipients is considered rare with only five such cases being reported worldwide.3 check details Moreover, mortality rates are high and diagnosis was established post-mortem in many instances. This case is the first LY2835219 disseminated microsporidiosis with Encephalitozoon species in a non-HIV, solid organ transplant recipient to be reported and successfully treated in Australia. None. “
“Cystatin-C (CysC) has been demonstrated as a sensitive and reliable biomarker to predict the onset of acute kidney injury (AKI). However, there are few studies concerned about the relationship between CysC and the outcomes of AKI. The aim of the present study was to determine whether CysC elevation prior to definite diagnosis of AKI is related to higher prevalence of death and dialysis
need outcome. A meta-analysis was conducted by searching PubMed, EMBASE and Cochrane Library database Glutathione peroxidase using the terms related to AKI combined with ‘cystatin-C’. Bibliographies of relevant papers were reviewed manually. Eligible studies were those investigating death and dialysis need outcomes after AKI with CysC measurement, and were limited to English articles. Non-human studies were excluded. Random effect Mantel-Haenszel statistical method was used. Six studies were finally enrolled, consisting of 2332 patients. All of these studies were hospital-based prospective cohort studies. The follow-up duration varied from 5 days to 1 year. The odds ratio values for baseline CysC elevation and death as well as baseline CysC elevation and dialysis
need were 2.34 (95% confidence interval [CI] 1.46–3.75) and 4.40 (95% CI 1.58–12.22), respectively (both P < 0.05). Patients with CysC elevated prior to AKI diagnosis have higher risk to develop death and need dialysis during short- and long-term follow-up after AKI, thus having worse outcomes. This population deserves more careful observation and might benefit from more frequent follow-up visits in the clinic. Future work is needed to get a consensus cut-off value defining CysC elevation. "
“Aim: To identify the variations in paediatric renal biopsy pathology and clinicopathological features during the past 31 years. Methods: A retrospective analysis of paediatric renal biopsies performed at a single institution in Shanghai from January 1979 to December 2009 was conducted.