In vitro, luliconazole is one of the most potent antifungal agents against filamentous fungi including dermatophytes. Luliconazole has been formulated in a 10% solution with unique molecular properties, which allow it to penetrate the nail plate and rapidly achieve fungicidal levels in the nail unit. These properties make luliconazole a potent compound in the treatment of onychomycosis. This article reviews the development of luliconazole solution, 10% its molecular
properties, preclinical and clinical data and its future perspectives for the treatment of fungal infections. “
“Incidence and mortality of candidaemia/invasive candidiasis (C/IC) learn more is relatively high in Latin America versus North America and Europe. To assess efficacy and safety of intravenous (IV) anidulafungin in Latin American adults with documented C/IC. All
patients in this open-label study received initial IV anidulafungin with optional step-down to oral voriconazole after 5 days; total treatment duration was 14–42 days. The primary endpoint was global response (clinical + microbiological response) at end of treatment (EOT); missing/indeterminate responses were failures. Crizotinib The study enrolled 54 patients; 44 had confirmed C/IC within 96 h before study entry and comprised the modified intent-to-treat population. Global response at EOT was 59.1% (95% CI: 44.6, 73.6), with 13 missing/indeterminate assessments. Thirty-day all-cause mortality was 43.1%. Fourteen patients (31.8%) were able to step-down to oral voriconazole;
these patients had lower baseline acute physiological assessment and chronic health evaluation (APACHE) II scores and were less likely to have solid tumours or previous abdominal surgery. Anidulafungin was generally well tolerated with few treatment-related adverse events. Anidulafungin was associated with relatively low response rates influenced by a high rate of missing/indeterminate assessments and mortality comparable to other recent candidaemia studies in Latin America. In a subset of patients with lower APACHE II scores, short-course anidulafungin followed Pregnenolone by oral voriconazole was successful. Candida spp. are the main cause of invasive fungal disease worldwide and an important cause of nosocomial bloodstream infections, primarily affecting those who are in an intensive care unit (ICU), neutropenic, elderly, transplant recipients, or premature neonates. Mortality attributable to candidaemia remains unacceptably high (general estimates range from 15 to 47% in adults) and is related to factors such as a lack of diagnostic sensitivity, comorbidities, severity of disease and causative Candida species.[2, 3] In Latin America, there are limited data available, but crude mortality rates for candidaemia in clinical studies are reported to be higher than in North America and Europe (50–54% vs. an average of ~31% respectively).