Ients, the development of the K Rpers. Since secretion of prolactin by the pituitary gland is modulated by tonic dopaminergic input, antipsychotics prolactin levels by blocking this effect can be obtained Hen. Puberty Ren children and young people can AZD6244 Selumetinib k The likelihood and Hyperprolaktin Chemistry with the anti-psychotic therapy to develop as they experience a decrease in age-related dopamine receptors can k. All first-generation antipsychotics acute Prolactin increased hen, But often spontaneously normalize serum levels over time, may need during the chronic treatment. Second-generation antipsychotics, on the other hand, affinity Th of dopamine D2 receptors varies and also vary in their R Ability, Hyperprolaktin Induce anemia.
Few studies have prospectively compared the effects of second-generation antipsychotic treatment prolactin levels in children and adolescents. 3.2.1. Schizophrenia A study CP-690550 JAK inhibitor by Saito et al. assesses changes in prolactin levels in children and adolescents with risperidone, olanzapine and quetiapine treatment. Prolactin levels were significantly h Ago, compared with risperidone, olanzapine or quetiapine and 25% of patients experienced adverse sexual side after treatment, independent Ngig of Prolactin and antipsychotic medication. The authors concluded that risperidone significant increase in prolactin levels in children and adolescents are caused, but that the duration of this Prolactinerh And increase their long-term effects in the treated population was unknown. 3.2.2.
Psychiatric disorders An analysis found the pooled data of studies that the gr H ere He was in prolactin levels in young patients aged 5-15 years, w During the first to second month of treatment with risperidone. The increase in prolactin was reduced in the wake like a drug, was continued until prolactin levels were back to normal at M And girls in the city Height of the normal range in the GAR Ons the end of 1 year. Thus, in this study did not show a direct correlation between high levels of prolactin and beautiful adverse effects that may be due to prolactin would. Nevertheless, the data should be interpreted with caution because they are obtained in patients with relatively low risk of Hten prolactin levels are based, and because the subjects puberty T can not be displayed, most side effects associated with the device T reproductive / sexual.
Based on the results of the present studies, risperidone has the gr-Run effect on prolactin levels, followed by haloperidol, olanzapine and ziprasidone, and with a medium effect and quetiapine, clozapine, aripiprazole, and with the least impact on prolactin. 3.3. Kardiovaskul Re effects of kardiovaskul Ren side effects may need during the treatment with antipsychotics were less hours Frequently reported in children and adolescents than in adults. All first-generation antipsychotics and second, a Loss EXTENSIONS QT corrected. This is obtained important because the extent of Tc with a Q Hten risk of potentially t Dlichen ventricular Re arrhythmia is associated. Two antipsychotics, ziprasidone and thioridazine are the hours Ufigsten with Q-Tc Verl Connected EXTENSIONS. Q-Tc Verl EXTENSIONS with ziprasidone was still only 10 ms l singer than with risperidone, quetiapine, olanzapine or judged. Schizophrenia an open prospective study was jointly.