The comparison group with the group Rhcg controlled Were used for the meta-analysis of more Rhcg. Method of randomization and secrecy were reported in 7 and 5 of the 12 individual studies. Definition of poor ovarian response, as well as the most important results vary between studies. Power analysis was performed in four studies and financial support has GSK256066 also been reported in 4 out of 12 individual studies. To inhibit premature LH, GnRH agonists were used in six studies, w While in five studies, a GnRH antagonist protocol was applied. In the study by Massin et al. two GnRH agonists and GnRH antagonists have been used, although the proportions of the different GnRH analog protocols are not statistically different between the two groups were compared.
Performed apart from the intervention that was evaluated in each study, stimulation of Eierst skirts with the use of recombinant Brivanib FSH in most studies, with the exception of one study that testedThe this systematic overview work and meta-analysis summarizes the best available data on the use of androgens or androgenmodulating agents before or need during the stimulation of Eierst skirts with gonadotropins in poor responders undergoing IVF. Based on the RCTs included in the current meta-analysis, there is limited evidence to suggest that a pretreatment testosterone patch improves the clinical pregnancy rate and live birth rates. On the other hand, no positive effect on pregnancy rate after IVF was in poor responders with DHEA, an aromatase inhibitor and hCG before or need during the stimulation of Eierst skirts recognized treatment.
In the case of adding rLH, supports data from only one study that can be the addition of rLH advantageous in terms of live births. In terms of clinical pregnancy rate, but the combination of f has the data from seven studies Rderf HIGEN no significant benefit for patients who again U rLH compared with those not. Although the statistical significance was not achieved, k nnte The size E of the effect size E and width of 95% with respect to the clinical pregnancy rates indicate a potentially clinically significant finding. Best to but the addition of new studies Term or reject such a theory, the R The beneficial dose of rLH in poor responders undergoing ovarian stimulation for IVF are not sufficient data available supports.
Analyzes of subgroups only m Were possible, in the case of rLH addition, due to the limited number of studies in other series. Analyzes have been demonstrated in studies on the exact date of it Opening more rLH were no significant differences both within and between the two subgroups of studies. Similarly, when studies were used by dose of rLH in these studies analyzed, there was no statistically significant difference between the three subgroups. It should be noted, however, that were in the subgroup of 75 150 IU, the common Sch Tzung the effect of these three studies statistically significant. Although not our right to refuse that this finding may be an underlying real effect, the M Possibility that there is a type I error should be seriously considered, made especially given the multiple comparisons statistics reflect repr Are presents. This systematic review and meta-analysis of RCTs follows a holistic approach