). Following the patient’s departure from the ED, the Vandetanib mechanism of action research nurse will identify the discharge medications, discharge location, length of stay in the Emergency Department and other general

details. Seven days following the departure from the ED, the research nurse will contact the patient and complete the phone follow up. At 28 days, the phone follow up will be Inhibitors,research,lifescience,medical repeated with a small section of repeated questions, which relate to any adverse events in the preceding days. The site visit is organised separately from the prospective data collection and will occur throughout the data collection period. The chart reviews will be completed following the end of the prospective data collection period. They will commence no sooner than two months after data collection had been completed. Inhibitors,research,lifescience,medical This will enable all relevant

information to be filed in the chart. All patient medical records will be recalled and the chart abstractors will review each chart using a pilot tested audit tool. Finally, no sooner than six months after the end of the prospective Inhibitors,research,lifescience,medical data collection, the data custodian will be contacted to request the relevant information regarding the index ED episode and any other hospital events up to and including 28 days post ED departure. The time lapse is to ensure that all data has been received Inhibitors,research,lifescience,medical from the State’s hospitals. Data compilation A recruitment database will be completed by the site nurse and forwarded, at regular intervals, to CRGM for review. The recruitment database will hold the general demographic information and the unique research identifies for each consenting patient. All data, assembled by the research nurse for prospective data collection, will be de-identified and forwarded to CRGM for data entry into an electronic database. Each file will be reviewed by one researcher for completeness prior to data entry. Any issues will be reconciled by request Inhibitors,research,lifescience,medical to the research nurse at each site. A second researcher will review all site visit data and request any missing

information from each site coordinator. The data will then be entered into an electronic database ready for analysis. Cilengitide Finally, the chart abstraction data collection tools will be forwarded to CRGM, identified only by the unique research ID, reviewed by one researcher for completeness and entered into an electronic database. A separate database will be established for each site. When all data is entered, and checked, the databases will be combined to establish one complete database ready for analysis. Phase 3: Expert panel and voting rounds Objective The purpose of the final expert panel is to enable panel to review the preliminary indicators alongside the data from the field study (phase 2) and revise or exclude indicators prior to the voting round.