JJCL, ARMD, ACL and JICS would like to www.selleckchem.com/products/kpt-8602.html acknowledge CONACYT and PIFI for their fellowships. JICS is also an ICYT-DF fellow. The authors would also like to acknowledge the Electron Microscopy Central of ENCB/IPN for technical assistance.

References 1. Lund FE, Garvy BA, Randall TD, Harris DP: Regulatory roles for cytokine-producing B cells in infection and autoimmune disease. Curr Dir Autoimmun 2005, 8:25–54.PubMedCrossRef 2. Batista FD, Iber D, Neuberger MS: B cells acquire antigen from target cells after synapse formation. Nature 2001, 411:489–494.PubMedCrossRef 3. Gupta N, DeFranco AL: Lipid rafts and B cell signaling. Semin Cell Dev Biol 2007, 18:616–626.PubMedCrossRef 4. Putnam Bafilomycin A1 solubility dmso MA, Moquin AE, Merrihew M, Outcalt C, Sorge E, Caballero A, Gondré-Lewis TA, Drake JR: Lipid raft-independent B cell receptor-mediated antigen internalization and intracellular trafficking. J Immunol 2003, 170:905–912.PubMed 5. Chiron D, Bekeredjian-Ding I, Pellat-Deceunynck C, Bataille R, Jego G: Toll-like receptors: lessons to learn from normal and malignant human B cells. Blood 2008, 112:2205–2213.PubMedCrossRef 6. Kato M, McDonald KJ, Khan S, Ross IL, Vuckovic S, Chen K, Munster D, MacDonald KP, Hart DN: Expression of human DEC-205 (CD205) multilectin

receptor on leukocytes. Int Immunol 2006, 18:857–869.PubMedCrossRef CDK assay 7. Won WJ, Bachmann MF, Kearney JF: CD36 is differentially expressed on B cell subsets during development and in responses to antigen. J Immunol 2008, 180:230–237.PubMed 8. Rappocciolo G, Piazza P, Fuller CL, Reinhart TA, Watkins SC, Rowe DT, Jais M, Gupta P, Rinaldo CR: DC-SIGN on lymphocytes is required for transmission of HIV-1 Axenfeld syndrome to T lymphocytes. PLoS Pathog 2006, 2:0691–0704. 9. Rappocciolo G, Hensler HR, Jais M, Reinhart TA,

Pegu A, Jenkins FJ, Rinaldo CR: Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN. J Virol 2008, 82:4793–4806.PubMedCrossRef 10. Li J, Barreda DR, Zhang YA, Boshra H, Gelman AE, Lapatra S, Tort L, Sunver JO: B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities. Nat Immunol 2006, 7:1116–1124.PubMedCrossRef 11. Krocova Z, Hârtlova A, Souckova D, Zivna L, Kroca M, Rudolf E, Macela A, Stulik J: Interaction of B cells with intracellular pathogen Francisella tularensis. Microb Pathog 2008, 45:79–85.PubMedCrossRef 12. Vidard L, Kovacsovics-Bankowski M, Kraeft SK, Chen LB, Benacerraf B, Rock KL: Analysis of MHC class II presentation of particulate antigens of lymphocytes B. J Immunol 1996, 156:2809–2818.PubMed 13. Barral P, Eckl-Dorna J, Harwood NE, De Santo C, Salio M, Illarionov P, Besra GS, Cerundolo V, Batista FD: B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo. Proc Natl Acad Sci USA 2008, 105:8345–8350.PubMedCrossRef 14.