Mol Microbiol 2003,50(2):475–486.PubMedCrossRef 5. Nguyen KT, Tenor J, Stettler H, Nguyen LT, Nguyen LD, Thompson CJ: Colonial differentiation in Streptomyces coelicolor

depends on translation of a specific codon within the adpA gene. J Bacteriol 2003,185(24):7291–7296.PubMedCentralPubMedCrossRef 6. McCormick JR, Flardh K: Signals and regulators that govern Streptomyces development. FEMS Microbiol Rev 2012,36(1):206–231.PubMedCentralPubMedCrossRef 7. StrepDB -The Streptomyces annotation server. http://​strepdb.​streptomyces.​org.​uk/​ 8. Gallegos MT, Schleif R, Bairoch A, Hofmann K, Ramos JL: AraC/XylS family of transcriptional regulators. Microbiol Mol Biol Rev 1997,61(4):393–410.PubMedCentralPubMed selleck chemicals llc 9. Egan SM: Growing repertoire of AraC/XylS activators. J Bacteriol 2002,184(20):5529–5532.PubMedCentralPubMedCrossRef 10. Yamazaki H, Tomono A, Ohnishi Y, Horinouchi S: DNA-binding specificity of AdpA, a transcriptional activator in the A-factor regulatory cascade in Streptomyces AZD4547 in vitro griseus . Mol Microbiol 2004,53(2):555–572.PubMedCrossRef

11. Horinouchi S: Mining and polishing of the treasure trove in the bacterial genus Streptomyces . Biosci Biotechnol Biochem 2007,71(2):283–299.PubMedCrossRef 12. Akanuma G, Hara www.selleckchem.com/products/repsox.html H, Ohnishi Y, Horinouchi S: Dynamic changes in the extracellular proteome caused by absence of a pleiotropic regulator AdpA in Streptomyces griseus . Mol Microbiol 2009,73(5):898–912.PubMedCrossRef 13. Hara H, Ohnishi Y, Horinouchi S: DNA microarray analysis of global gene regulation by A-factor in Streptomyces griseus . Microbiology 2009,155(Pt 7):2197–2210.PubMedCrossRef 14. Higo A, Hara H, Horinouchi S, Ohnishi Y: Genome-wide distribution of AdpA, a global regulator for secondary metabolism and morphological differentiation in Streptomyces , revealed the extent and complexity of the AdpA regulatory network. DNA Res 2012,19(3):259–274.PubMedCentralPubMedCrossRef 15. Lee HN, Kim JS, Kim P, Lee HS, Kim ES: Repression

of antibiotic downregulator WblA by AdpA in Streptomyces coelicolor . Appl Environ Microbiol 2013,79(13):4159–4163.PubMedCentralPubMedCrossRef 16. Wolanski M, Donczew R, Kois-Ostrowska A, Masiewicz P, Jakimowicz D, Zakrzewska-Czerwinska J: The level of AdpA directly affects MycoClean Mycoplasma Removal Kit expression of developmental genes in Streptomyces coelicolor . J Bacteriol 2011,193(22):6358–6365.PubMedCentralPubMedCrossRef 17. Liu G, Chater KF, Chandra G, Niu G, Tan H: Molecular regulation of antibiotic biosynthesis in Streptomyces . Microbiol Mol Biol Rev 2013,77(1):112–143.PubMedCentralPubMedCrossRef 18. Kato J, Ohnish Y, Horinouchi S: Autorepression of AdpA of the AraC/XylS family, a key transcriptional activator in the A-factor regulatory cascade in Streptomyces griseus . J Mol Biol 2005,350(1):12–26.PubMedCrossRef 19. Ohnishi Y, Yamazaki H, Kato JY, Tomono A, Horinouchi S: AdpA, a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus .