Pathway, the of LPS to activate NF . The inhibitory Rocuronium Zemuron effect on NF BP5 activation co F filled With attenuated Want NO, ROS, TBARS and protein carbonyls, and this D Mpfungen is a negative regulation of gene expression and produced iNOS and iNOS activity T through the regulation of GSH content and antioxidant enzyme activity Ten. Considering that NF is a factor of redox-sensitive and an important regulator of antioxidant enzymes, we conclude that the mechanism by which reduced intracellular BP5 Ren and oxidative stress associated with suppression of NF activation associated. In summary, protects BP5 LPS activated murine peritoneal macrophages by oxidative stress by reducing the production of NO, ROS, lipid peroxidation and protein oxidation. This protective effect is to modulate BP5 F ability, iNOS expression and activity of t-cycle and to inhibit glutathione redox and antioxidant enzymes. The suppressive effect of oxidative stress on BP5 is shown via downregulation of the expression and activity t of nuclear factor kappa B This study showed that BP5 have k Can applications as a new reagent anti-oxidative stress. Parkinson’s disease leading St Tion a neurodegenerative St Tion, the progressive loss of nigrostriatal dopaminergic neurons characterized by. Although the exact Aetiological factors yet to be determined, a variety of pesticides, insecticides, heavy metals and induce aberrant production of reactive oxygen species and cause oxidative Sch In the dopaminergic neurons. Current therapies for Parkinson’s disease h Lengths Haupts Chlich of antioxidants and the replacement of dopamine with the drug levodopa. L Dopa is a psychoactive drug, natural and an important precursor of dopamine, noradrenaline and adrenaline.
L Dopa can easily cross the blood-brain barrier Etoposide protects the brain, w During dopamine itself can not. L Dopa is converted to dopamine by DOPA decarboxylase in the central nervous system. It is known that dopamine is oxidized and is itself oxidized by monoamine oxidase, MAO-A andMAO known and B, ROS production and its toxic metabolites, such as 3,4 and 3,4 Dihydroxyphenylessigs dihydroxyphenylacetaldehyde Acid. Interestingly, intracellular Ren antioxidant molecules, such as reduced glutathione fa Used within concurrent dopaminergic neurons. It should be noted that the most important DOPAL is neurotoxic metabolite of dopamine, w While GSH is essential for cellular Re Hom Homeostasis in dopaminergic cells. Sun dopamine toxicity t is an unavoidable problem in L dopa therapy is based on Parkinson’s disease . In addition, a variety of synthetic or natural antioxidants for the M Opportunity were to prevent or reduce the progression of Parkinson’s disease evaluated . These antioxidants k Can in their R Ability, between the different types of free radicals to l And to vary the interaction with different cellular Ronments in terms of their lipophilic and hydrophilic properties. However, supplementation with antioxidants produced more reasonable rates in sweeping free radicals to help in the metabolism of L dopa and improve the effectiveness of L-dopa therapy. Z is an inducer electrophilic ligustilide lipophilic from Heilkr Utern Chuanxiong Rhizoma and Radix Angelicae Sinensis, which was isolated.