In our study, the serum VEGF level was altered in different clinical subtypes of OLP with the erosive/atrophic form showing a particularly increased
level. This finding was consistent with another study showing that angiogenesis and VEGF expression were strongly correlated to different clinical form of OLP lesions.1 The serum Inhibitors,research,lifescience,medical VEGF level is associated with disease activity in a large number of autoimmune diseases including rheumatoid arthritis, psoriasis and osteoarthritis.20 Increased level of VEGF in the atrophic erosive group implies that angiogenesis can be an implicit indicator of disease activity of OLP. Previous immunohistochemical studies have revealed that angiogenetic phenomenon is present in the malignant transformation Inhibitors,research,lifescience,medical of many precancerous lesions of the oral epithelium, including OLP.21 Thus, greater tendency for malignant transformation reported in erosive OLP lesions,21 may be related to the increased angiogenesis.21 Some studies have demonstrated a reduction in serum VEGF concentrations after therapeutic intervention.22 Considering the expression
of the inducing factors of angiogenesis, new therapeutic modalities based on the use of anti-angiogenic medicine should be considered. These medications are already used in other pathologies with chronic inflammatory pathogenesis Inhibitors,research,lifescience,medical and are yielding good results.12 Many studies have shown that anti-angiogenic treatment, can decrease disease severity and delay the progression Inhibitors,research,lifescience,medical of chronic inflammation in some autoimmune and inflammatory diseases through the specific inhibition
of VEGF.23,24 Considering the poor response to routine immunosuppressive or anti-inflammatory treatment in some patients with OLP, and regarding the role of angiogenesis Inhibitors,research,lifescience,medical and VEGF expression in OLP, angiogenesis can be used as an efficient target for therapeutic strategies.20 One of the limitations of our study was that we did not have the post treatment serum samples of the patients Dacomitinib and therefore, we could not compare VEGF levels before and after treatment. Conclusion The analysis of serum VEGF may serve as a useful and convenient marker to scrutinize the activity of OLP. However, further studies are recommended to measure serum VEGF level after therapeutic intervention using anti-angiogenic strategies to evaluate the role of VEGF in the treatment of OLP. Acknowledgment The authors would like to thank the Vice-Chancellor for Research Affairs of Shiraz University of Medical Sciences for providing the financial support for this study (grant # 90-5275). Conflict of interest: None declared
Background: During pregnancy and lactation outstanding changes occur in mother’s vitamin D metabolism.