The current studies analyzed the efficacy of anti-LFA-1 mAb to inhibit early CD8 T cell cardiac allograft infiltration and activation. Anti-LFA-1 mAb given GDC-0068 to C57BL/6 6 (H-2b) recipients of A/J (H-2a) heart grafts on days -1 and 0 completely inhibited CD8 T cell allograft infiltration, markedly decreased neutrophil infiltration and significantly reduced intragraft expression levels of IFN-gamma-induced genes. Donor-specific T cells producing IFN-gamma were at low/undetectable numbers in

spleens of anti-LFA-1 mAb treated recipients until day 21. These effects combined to promote substantial prolongation (from day 8 to 27) in allograft survival. Delaying anti-LFA-1 mAb treatment until days 3 and 4 posttransplant did not inhibit early VS-4718 supplier memory

CD8 T cell infiltration and proliferation within the allograft. These data indicate that peritransplant anti-LFA-1 mAb inhibits early donor-reactive memory CD8 T cell allograft infiltration and inflammation suggesting an effective strategy to attenuate the negative effects of heterologous immunity in transplant recipients.”
“During our search to discover new antitrypanosomal compounds, eight known plant compounds (three phenolic compounds and five kawa lactones) were evaluated for in vitro activity against Trypanosoma brucei brucei. Among them, we found two phenolic compounds and three kawa lactones possessing an alpha-pyrone influenced antitrypanosomal property. In particular, beta-phenethyl caffeate, farnesyl caffeate and dihydrokawain exhibited high or moderate selective and potent antitrypanosomal activity in vitro. We detail here the antitrypanosomal activity and cytotoxicities of the compounds, in comparison with two commonly used antitrypanosomal drugs (eflornithine and suramin). Selleck SYN-117 Our findings represent the first report of the promising trypanocidal activity of these compounds.”
“The clinical course of abducens nerve palsy associated with skull base tumour is rarely reported. In this study, we examined

the post-operative course of abducens nerve palsies associated with various skull base tumours.

Between January 2003 and December 2006, 240 patients with various skull base tumours underwent surgery at Kyushu University Hospital. Among them, nine patients presented with abducens nerve palsies (ten nerves) following surgery. The conditions included two pituitary adenomas, two trigeminal schwannomas and five meningiomas. We evaluated the function of the abducens nerves in these patients on admission, at discharge, and periodically in the outpatient clinic.

Four of the abducens nerve palsies already existed prior to surgery, and six of them developed post-operatively. In the four patients with pituitary adenomas and trigeminal schwannomas, all nerves were anatomically preserved and showed complete recovery of function within 6 months after surgery.

Diagnoses were as follows: eight conrescent teeth, two fused teeth, two geminated teeth and one invaginated tooth. selleck compound The anomaly of a deciduous tooth was referred to in one case only. Double teeth were most often seen in the

region of maxillary incisors and molars but rarely in the mandible. The region of incisors was affected chiefly in children and the region of molars in adults. Double incisors are usually recognized prior to treatment whereas double molars as late as during their extraction. In many cases, neither intraoral radiographs nor pantomographs help to confirm double teeth or provide sufficient information to plan the treatment. In such a situation, CT or CBCT should be used in addition to imaging diagnostics. Double teeth among incisors are usually accompanied by occlusal disorders. Therefore the therapeutic management is conducted buy DMXAA by a team, including orthodontists.”
“BACKGROUND: Heterotopic pregnancy describes the relatively rare coexistence of one or

more intrauterine gestations and one or more extrauterine (ectopic) gestations. We describe a unique clinical case involving successful treatment of an ovarian heterotopic pregnancy through gestational sac aspiration and injection of hyperosmolar glucose.

CASE: A 31-year-old woman presented with an ovarian ectopic pregnancy and a viable intrauterine pregnancy after ovulation induction with oral medications. The ovarian

gestational sac was aspirated and then injected transvaginally with a small volume of 50% glucose in water. The ectopic pregnancy resolved, and the intrauterine pregnancy was delivered at term without complication.

CONCLUSION: Gestational sac aspiration and see more injection of hyperosmolar glucose into an ovarian ectopic pregnancy was simple and efficacious without compromising a coexisting intrauterine pregnancy. (Obstet Gynecol 2012;120:449-52) DOI: 10.1097/AOG.0b013e31824f6379″
“Objective.

In response to the Accreditation Council for Graduate Medical Education’s (ACGME) new pain medicine fellowship requirement, which emphasizes multidisciplinary training strategies aimed at providing improved clinical care for pain patients, we developed a multidisciplinary team training education model for trainees in our institution’s Fellowship Program in Pain Medicine. Although the biopsychosocial model guides the delivery of care by multidisciplinary pain teams, there is a gap on how to improve team attitudes and functioning within an already extensive pain medicine curriculum.

We report our experience with aberrant right hepatic arterial anatomy (ARHAA) found during PD.

Methods: All patients who underwent PD between February 2003 and June 2007 were retrospectively reviewed and those with ARHAA were identified. Preoperative

imaging studies were assessed by one radiologist, graded according to the presence of ARHAA and compared with the original interpretations.

Results: We found ARHAA in 31 of 191 patients (16.2%). Operative management included dissection and preservation in 24, transection and reconstruction in four, and transection and primary anastomosis in three patients. Reconstruction of ARHAA was carried out through interposition grafts in two patients and implantation Nepicastat into the gastroduodenal stump in two patients. No cases of arterial thrombosis, liver infarction, abscess formation or biliary fistula were demonstrated in the immediate postoperative period. Review of preoperative imaging interpretations found that only nine of 23 reports indicated the presence of ARHAA; however, the retrospective review of the images found that ARHAA was readily Combretastatin A4 price apparent in 24 patients.

Discussion: Recognition of aberrant vasculature to the liver before PD is important. Preoperative imaging studies will often be adequate to identify these anomalies, but interpreting radiologists may

not be aware of its clinical significance. Surgeons performing PD must be adept at managing ARHAA safely.”
“Neuroblastoma is the most common extracranial solid tumor in pediatric age group. Clinical presentation of neuroblastoma is

mostly related to origin of the tumor, extent of disease, and the presence of paraneoplastic syndromes. Here the authors report a neonate with neuroblastoma with an atypical presentation, diagnosed with postnatal abdominal ultrasonography performed due to polyhydramniosis in her mother during pregnancy.</.”
“With regard to surface appearance, the angle-resolved light scattering from textured polymeric surfaces was evaluated to link the reflectance properties to measured gloss as well as visually perceived gloss. Bidirectional reflectance distributions were determined by means of a scatterometer and the specimens involved were textured injection-molded selleck chemicals llc plaques manufactured from three different polymers; an acrylonitrile-butadiene-styrene (ABS) copolymer, a polypropylene (PP), and a polycarbonate and ABS copolymer blend (PC/ABS). The influence of color, surface roughness, and angle of incidence on the scattering characteristics was evaluated. An off-specular reflectance peak was observed for the textured specimens the magnitude of which was clearly determined by the surface roughness and the angle of incidence. The color of the specimens mainly influenced the diffuse reflectance.

While incomplete electrode insertion does not necessitate poor speech performance, some patients with incomplete electrode insertion certainly experience it. Therefore, electrode selection requires circumspection in revision CI. Choosing a thinner electrode for revision CI may reduce the possibility of incomplete electrode insertion.”
“Recently the importance in nephrology of phosphorus as phosphate has been highlighted by chronic renal failure patients, in whom the toxic effect of phosphate is widely acknowledged, given the association of phosphate serum level with cardiovascular

risk. This association FDA-approved Drug Library chemical structure is not limited to chronic renal failure and hemodialysis patients as high serum phosphate. Recently high serum phosphate levels were associated with increased risk for cardiovascular

disease in subjects free from chronic kidney disease, and cardiovascular disease as well, and with progression of atherosclerosis. It is useful to know the history of phosphorus from its discovery in 1669, because that history gives us more evidence to better understand the negative and/or toxic effects of high phosphate serum levels and to identify phosphorus as a physiologically crucial anion.”
“Ventricular free wall rupture is a rare, usually fatal complication of acute myocardial infarction. Subacute free wall rupture with pseudoaneurysm formation is even rarer, but may be associated with a chance of survival if surgery is performed expeditiously. Although rupture of the left ventricle AZD8931 is more common, right-sided rupture has also been reported. We report an unusual case of post-infarct biventricular rupture masquerading as a ventricular septal defect, due to an extracardiac shunt within the pseudoaneurysm. Our patient underwent urgent surgery, made an excellent recovery and was discharged home in a fully functional condition within a week post-surgery.”
“Neuropsychological studies reported decoding deficits of emotional facial expressions in alcohol-dependent patients, and imaging studies revealed reduced prefrontal MK-0518 and limbic activation

during emotional face processing. However, it remains unclear whether this reduced neural activation is mediated by alcohol-associated volume reductions and whether it interacts with treatment outcome. We combined analyses of neural activation during an aversive face-cue-comparison task and local gray matter volumes (GM) using Biological Parametric Mapping in 33 detoxified alcohol-dependent patients and 33 matched healthy controls. Alcoholics displayed reduced activation toward aversive faces-neutral shapes in bilateral fusiform gyrus [FG; Brodmann areas (BA) 18/19], right middle frontal gyrus (BA46/47), right inferior parietal gyrus (BA7) and left cerebellum compared with controls, which were explained by GM differences (except for cerebellum).

2%, a positive predictive value (+ P) of 99.1%, with an average trigger delay and jitter of 5.8 ms and 5.0 ms, respectively. Long term stability of the demixing matrix was shown based on two measurements of the same subject, each being separated by one year, whereas an averaged detection performance of Se = 99.4% and + P = 99.7% was achieved. Compared to the state-of-the-art

VCG-based gating technique at 7 T, the proposed method increased the sensitivity and positive predictive value within the test dataset by 27.1% and 42.7%, respectively.

Conclusions: The presented ICA-based method allows the estimation and identification of an IC dominated by the ECG signal. R-peak detection based on this IC outperforms the state-of-the-art VCG-based technique in a 7 T MR scanner environment.”
“Objetive To study the validity DZNeP concentration of Dynamic Urethral Resistance Relation (DURR) CT99021 order for differential diagnosis between static and dynamic urinay obstruction in male spinal cord injury patients. Methods: A case-control study was conducted. The case group consisted of 24 male patients with spinal cord injury, aged under 40 years, with detrusorperiurethral sphincter dyssynergia and bladder outlet obstruction (BOO) according to the urethral resistance factor (URA). The control group consisted of 24 male patients with no neurological lesions, aged over 49 years, diagnosis of benign

prostatic hyperplasia (BPH) and BOO according to Scha “”fer’s minimum urethral opening pressure (Pmuo) and the URA. A pressure/ flow study was performed in both groups, and the DURR was recorded graphically. Results: Both groups showed significantly different

DURR characteristics with respect to the number of spikes (higher in the case group), the intensity of the first three spikes and the maximum duration of the spikes (significantly longer in the case group). The patients in the case group had a DURR characterized by at least three spikes, Entinostat solubility dmso located throughout the whole voiding cycle (pattern A). The patients in the control group had a DURR mainly characterized by a spike located at the start of micturition and a maximum second spike located at the end of micturition (pattern B). Conclusions: Pattern A showed a sensitivity with respect to the dynamic obstruction of 79% and a specificity of 100%. The sensitivity of pattern B with respect to the diagnosis of static obstruction was 71% and the specificity was 100%. Neurourol. Urodynam. 31: 549-555, 2012. (C) 2012 Wiley Periodicals, Inc.”
“Objective: Evaluate the clinical use of a preoperative protocol using hearing-in-noise improvement as measured by Adaptive HINT and Quick SIN in patients undergoing ossseointegrated hearing implantation for single-sided deafness (SSD).

Study Design: Prospective cohort.

Setting: Tertiary academic hospital and clinic.

At Week 48 they were 4.1 log(10) (max. 7.4, min. 1.0) and 2.3 log(10) (max. 7.5, min. 0.3) (Z = -2.760, P = 0.006), respectively. For intrahepatic HBV DNA load they were 1.3 log(10) (max. 4.3, min. -1.2) and 0.6 log(10) (max. 3.5, min. buy TH-302 -0.8), respectively, and for HBV cccDNA load they were 1.1 log(10) (max. 4.8, min. -0.5) and 0.5 log(10) (max. 3.0, min.

-0.8) (Z = -2.097, P = 0.036), respectively at Week 48. Step-wise logistic regression analysis indicated that the baseline intrahepatic HBV DNA load effected virological response at Week 12 [odds ratio (OR) 0.405; 95% confidence interval (CI) 0.174-0.944; P = 0.036] and HBeAg seroconversion at Week 48 (OR 0.292; 95% CI 0.131-0.649; P = 0.003). In conclusion, virological response at Week 12 indicated a great reduction of intrahepatic DNA and cccDNA load in HBeAg-positive CHB patients. The baseline intrahepatic HBV DNA load affected virological response at Week 12 and HBeAg seroconversion at Week 48.”
“The objective was to determine whether pregnancy loss after amniocentesis is related to the

amount of amniotic fluid obtained during the procedure.

The study enrolled 2,400 women, all in their sixteenth to twentieth week of pregnancy. A 22G spinal needle was inserted for amniocentesis. The amount of amniotic fluid obtained from 1,200 patients in Group 1 was 4 ml and from 1,200 patients in Group 2 was 20 ml. In Group 1, the amniotic fluid was analyzed with a quantitative fluorescent polymerase

chain reaction technique, whereas in Group 2, conventional cytogenetic analysis was used. selleck chemical SPSS 16.0 (chi-square and t tests) was used for statistical analyses.

In Group 1, postamniocentesis premature rupture of membranes (PROM) occurred in four patients (0.3%). There was one unintended GW4869 chemical structure fetal loss and postamniocentesis miscarriage rate was 0.08%. In Group 2, postamniocentesis PROM occurred in 12 patients (1%). Eight of these patients experienced fetal loss (0.67%). Fetal loss rates were higher in Group 2 compared with Group 1. These results did not show statistical differences between the groups according to chi-square test (P > 0.05).

Although statistical analysis denies the positive effect of obtaining small amounts of amniotic fluid to reduce fetal loss rates in patients after amniocentesis, six to eight times lower fetal loss rates based on the amount of fluid obtained cannot be undervalued.”
“Aims We describe our aim to create a zero-error system in our pediatric ambulatory surgery center by employing effective teamwork and aviation-style challenge and response flow checklists’ at key stages of the patient surgical journey. These are used in addition to the existing World Health Organization Surgical Safety Checklists (Ann Surg, 255, 2012 and 44). Background Bellevue Surgery Center is a freestanding ambulatory surgery center affiliated with Seattle Children’s Hospital, WA, USA.

The preliminary results suggest that the oxidative polymerization process could be improved

to yield polythiophenes with higher regioregularity degree and narrower molar mass distributions by just setting some reaction conditions. We also verified that it is possible to solvent extract part of the lower regioregular fraction of the polymer MI-503 nmr further improving the regioregularity degree. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012″
“The relationship between the composition and the kesterite crystal structure of Cu2ZnSnS4 (CZTS) thin films was investigated. CZTS thin films with three different compositions were produced by sulfurizing the precursors in 5 vol. % H2S balanced with N-2. We measured the x-ray diffraction patterns of the CZTS powders scraped away from the

CZTS thin films using the synchrotron radiation. The site occupancy of the CZTS thin films that had respectively different compositions were determined by the Rietveld analysis using x-ray powder diffraction patterns. Zn substitutes for Cu at the 2a site with 3-deazaneplanocin A purchase decreasing the value of composition ratio Cu/(Zn+Sn). Meanwhile, Cu substitutes for Sn at the 2b site with increasing the value of Cu/(Zn+Sn). The CZTS thin film with Cu/(Zn+Sn) = 0.8 especially shows a marked tendency that Cu substitutes for Zn at the 2d site and/or Zn substitutes for Cu at the 2c site compared to the CZTS thin films with Cu/(Zn+Sn) = 1.0 and 1.2. We suppose

that it is very important to realize the high performance of the photovoltaic generation that CZTS thin films have kesterite crystal structure substituted for Zn at the 2d by Cu and/or substituted for Cu at the 2c site by Zn. (c) 2011 American Institute of Physics. [doi: 10.1063/1.3642993]“
“Brucellosis produces a variety of nonspecific hematologic abnormalities. Hematologic complications of mild anemia and leukopenia have been frequently associated with acute brucellosis, but pancytopenia is less frequently seen. In this study, records of children with brucellosis aged check details under or equal to 16 years, admitted to Yuzuncu Yil University Hospital between 2004 and 2010, were analyzed retrospectively. Over this time period, 187 patients with brucellosis were diagnosed. Twenty-five (13.3%%) of 187 patients had pancytopenia during admission to hospital. The diagnosis of brucellosis was confirmed by standard tube agglutination test in all patients; titers were 1:320 in 1 patient and 1:1280 in 24 patients. Blood culture was positive for Brucella melitensis in 3 patients (12%%). Fever was the most common manifestation, followed by malaise, anorexia, sweating, and weight loss. Fever and splenomegaly were the common signs in most patients. In addition, arthritis was observed in 5 patients, and epistaxis, headache, and abdominal pain were observed in 3 patients.

We hydrolyzed the hard tissue and coextruded it with soybean hulls to create a novel feather and bone meal (FBM) containing 94.2% DM, 23.1% CP, 54.5% NDF, and 7.3% fat (DM basis). We evaluated the FBM in supplements for meat goats in which it provided 0, 20, 40, or 60% of the N added to the supplement compared with a negative control supplement with no added N source. The remainder of the N was contributed by soybean meal (SBM). Supplementation of N resulted in greater DMI than the negative control (P = 0.005), and DMI changed quadratically (P = 0.11) as FBM increased in the supplement.

IPI 145 Digestibility of DM was similar in all diets, including the negative control (P > 0.10). Fiber digestibility increased linearly as dietary inclusion Batimastat price of FBM increased (P = 0.04 for NDF, P = 0.05 for ADF), probably as a result of the soybean hulls in

the FBM. Nitrogen digestibility declined linearly from 60.5% with 0% FBM to 55.6% with 60% FBM (P = 0.07), but N retention changed by a quadratic function as FBM replaced SBM (P = 0.06). Negative control goats had less N digestibility (P < 0.001) and N retention (P = 0.008) than N-supplemented goats. Feather and bone meal had a greater proportion of ruminally undegradable B3 protein than SBM (23.1 vs. 0.3% of CP, respectively). Ruminal VFA and pH were unaffected by replacing SBM with FBM, but supplying no source of N in the concentrate resulted in reduced total VFA in ruminal fluid (P = 0.04). Ruminal ammonia concentration increased quadratically (P = 0.07) as FBM increased, reflecting increased intake, and it was much less in unsupplemented goats (P < 0.001). Serum urea had less variation between 0 and 4 h after feeding in goats receiving 40 or 60% of added N as FBM in comparison with those receiving only SBM or 20% FBM. Feather and bone meal promoted a more stable rumen environment, possibly because of reduced rates of protein degradation within the rumen. A palatable by-product meal for ruminants can be made from spent laying hen hard tissue, one that supports N metabolism similar to that of traditional protein sources.”
“Photonic crystal patterns on the indium tin oxide layer of

an InGaN/GaN light-emitting diode are fabricated via nanosphere lithography in combination with dry etching. The silica spheres acting as an etch mask are self-assembled into a hexagonal closed-packed monolayer selleck chemicals array. After etching, the photonic crystal (PhC) pattern is formed across the indium-tin-oxide (ITO) films so that the semiconductor layers are left intact and thus free of etch damages. Despite slight degradation to the electrical properties, the ITO-PhC light-emitting diodes (LEDs) exhibit enhancements of their optical emission power by as much as 64% over an as-grown LED. The optical performances and mechanisms of the photonic crystal LEDs are investigated with the aid of rigorous coupled wave analysis and finite-difference time-domain simulations.

0001). No significant differences in complications were noticed between the three groups. Efficacy of combining POL and laser proved safe and satisfactory in 96 % of patients using low-fluence laser pulses with a total cumulative energy in the 3 cm venous segment, lower than that of conventional treatment. Very few and transient complications were observed. POL foam injection followed by laser

pulses is safe and efficient for vein treatment in dark-skinned patients.”
“It is a widely held view that drug response genes have not proved as useful in clinical practice as anticipated https://www.selleckchem.com/products/qnz-evp4593.html at the start of the genomic era. An exception is in the treatment for chronic hepatitis C virus (HCV) genotype 1 infection with pegylated interferon a and ribavirin. In 2009, four independent genome-wide analyses identified IL28B polymorphisms that predict drug response in chronic hepatitis C (CHC). This discovery had immediate clinical impact. First, the IL28B genotype could be used to personalize

therapy. In the 2 years since discovery, most of the more than 100,000 CHC patients commencing therapy for CHC in the West will have considered IL28B genotype testing. Second, the discovery has supported clinical trials for the use of the protein encoded by the gene known as interferon lambda. Third, it is expected that new insights into HCV pathogenesis will follow from studies of how IL28B affects HCV viral clearance and, ultimately, this will lead to new therapeutic PR-171 mw strategies for CHC. This review discusses how IL28B genotyping is now used in personalizing therapy and, with the dramatically changing clinical landscape in CHC, with the advent of direct-acting antivirals, the prospects ahead.”
“The present study was carried out to evaluate the antioxidant capacity of the aerial parts of ethanol crude extracts and their four solvent fractions (hexane (HF), ethyl GDC-0941 manufacturer acetate (EAF),

butanol (BuOHF), and aqueous (WF)) of three selected Algerian Lamiaceae: Calamintha clinopodium, Teucrium flavum and Thymus algeriensis. The extracts of the three Lamiaceae were evaluated for their total phenols, flavonoids, flavonols content and antioxidant activity (reducing power, total antioxidant capacity, DPPH radical and hydrogen peroxide scavenging effect). WF of T. algeriensis was the most effective fraction with 75.13 mg ascorbic acid equivalent (AscA E)/g of powder for reducing power, and 218.37 mg(AscA E)/g of powder for total antioxidant activity. It also showed the highest DPPH and hydrogen peroxide scavenging capacities with IC50 values of 0.01 and 0.08 mg/mL, respectively. Moreover, WF of T. algeriensis exhibited higher total phenolic content (99.21 mg gallic acid equivalent (GAE)/g of powder). Aqueous fraction of T. algeriensis has a strong ability to act as antioxidant, and may be considered as a natural source of active compounds. (C) 2013 Elsevier B.V. All rights reserved.”
“Introduction: The vast majority of infants in published studies regarding laryngomalacia are Caucasian.

Pediatricians and obstetricians should be aware of the possibility of this infectious disease when examining newborns with fever. These observations suggest that antenatal maternal screening for S. dysgalactiae subsp. equisimilis should be considered.”
“The magnetoplasmon spectrum of two-dimensional electron

gas systems with both Rashba and Dresselhaus spin-orbit interactions is investigated theoretically. The coexistence of the two types of spin-orbit interactions leads to resonant Volasertib mw splittings of the collective excitation modes and makes the magnetoplasmon spectrum anisotropic with respect to the direction of the wave vector. The anticrossing gaps in the magnetoplasmon spectrum vary with the angle of the wave vector and reach their extrema at several fixed directions. Such anisotropic splittings could be used to evaluate the relative strength of the Rashba and Dresselhaus spin-orbit interactions in two-dimensional electron systems. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3583651]“
“Recurrent cytomegalovirus (CMV) infections commonly occur after kidney transplantation. We

studied the impact of secondary prophylaxis and other factors on the risk of CMV recurrence. All kidney transplant recipients between 2004 and 2009 in our institution were analyzed (N = 254). Patients with CMV infection were included (N = 62). CMV infections were diagnosed with quantitative PCR. CMV D+/R- recipients received selleck 6 months valganciclovir prophylaxis, after which DNAemia was monitored. After treatment, secondary prophylaxis

Smoothened Agonist research buy with valganciclovir was given at the clinician’s discretion for 2-26 weeks and CMV DNAemia was monitored. Altogether 43 reactivations and 19 primary infections occurred. Antiviral treatment with valganciclovir or ganciclovir was given to 45 patients; 34/62 (55%) patients received secondary prophylaxis for mean 62 days (range 14-180 days). CMV recurrence occurred in 14/43 (33%) seropositive patients and in 4/19 (21%) patients after primary infection. In logistic regression, delayed graft function (OR 3.4) and high viral load (> 100 000 copies/ml) at initial diagnosis (OR 5.9) predicted recurrence. Use or length of secondary prophylaxis, CMV serostatus, level of immunosuppression, HLA mismatch, antiviral treatment, or time to clearance of viremia during treatment did not predict recurrence of CMV. CMV recurrences occur commonly despite secondary prophylaxis. High viral load at diagnosis predicted the risk of recurrent CMV infection.”
“Varicella is usually a benign and self-limited disease of infancy and childhood although it has been recognized that it sometimes has severe and life-threatening complications. We report a case of postinfectious purpura fulminans with acquired protein S deficiency following varicella in a 6-year-old child and discuss the underlying mechanism of postinfectious purpura fulminans.